将大脑与心肌梗塞后的恢复联系起来

IF 9.4 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Nature cardiovascular research Pub Date : 2024-07-12 DOI:10.1038/s44161-024-00497-x

Dylan C. Sarver, Aldons J. Lusis

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摘要

心肌梗塞会损伤心肌并导致心力衰竭。有关恢复的研究通常侧重于浸润的免疫细胞、受损的心肌细胞、过度刺激的成纤维细胞和血管的变化。海金等人现在描述了在修复过程中连接这些实体（包括大脑和肝脏）的多器官回路。

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Linking the brain to recovery after myocardial infarction

Myocardial infarction can damage the heart muscle and lead to heart failure. Research on recovery typically focuses on infiltrating immune cells, damaged cardiomyocytes, over-stimulated fibroblasts and changes in vasculature. Haykin et al. now describe a multi-organ circuit linking these entities, including the brain and liver, in the repair process.

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