Eshita Sharma, Manju Tewari, Priyanka Sati, Isha Sharma, Dharam Chand Attri, Supriyanka Rana, Afaf Ahmed Aldahish, Daniela Calina, Praveen Dhyani, Javad Sharifi-Rad, William C. Cho
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引用次数: 0
摘要
全球癌症负担的不断加重凸显了对更有效治疗策略的迫切需求。植物化学物质是植物中天然存在的化合物,因其在癌症化学预防和化疗方面的潜力而备受关注。它们调节分子机制和影响细胞信号通路的能力为癌症治疗提供了一条前景广阔的途径。本综述旨在综合目前有关植物化学物化学预防和化学治疗潜力的知识,重点关注其分子作用机制以及对癌症相关细胞信号通路的影响。我们在主要数据库(包括 PubMed/Medline、Web of Science、Scopus 和 Google Scholar)中进行了系统的文献检索。搜索策略使用医学主题词表(MeSH)和自由文本术语,并使用布尔运算符捕捉相关研究。纳入标准以植物化学物质对癌症影响的原始研究和综述为目标,特别关注分子机制。植物化学物质(包括类黄酮、多酚和萜类化合物)通过诱导细胞周期停滞、细胞凋亡和自噬而显示出显著的抗癌特性。它们能调节关键的细胞信号通路,如环氧化酶-2、核因子卡巴 B 和各种生长因子相关通路,并纠正表观遗传学改变,从而产生化学预防和治疗效果。植物化学物质是开发新型癌症预防和治疗策略的宝贵资源;它们对分子机制和细胞信号通路的作用凸显了其在癌症预防和抗击方面的潜力。要将这些发现转化为临床应用,优化基于植物化学物质的癌症管理干预措施,还需要进一步的研究。
Serving up health: How phytochemicals transform food into medicine in the battle against cancer
The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention for their potential in cancer chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms and influence cell signaling pathways offers a promising avenue for cancer management. This review aims to synthesize current knowledge on phytochemicals’ chemopreventive and chemotherapeutic potential, focusing on their molecular mechanisms of action and impacts on cell signaling pathways involved in cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web of Science, Scopus, and Google Scholar. The search strategy uses Medical Subject Headings (MeSH) and free-text terms using Boolean operators to capture relevant studies. Inclusion criteria targeted original research and reviews on the effects of phytochemicals in cancer, with a specific focus on molecular mechanisms. Phytochemicals, including flavonoids, polyphenols, and terpenoids, demonstrated significant anticancer properties by inducing cell cycle arrest, apoptosis, and autophagy. They modulate critical cell signaling pathways, such as cyclooxygenase-2, nuclear factor kappa B, and various growth factor-related pathways, and rectify epigenetic alterations, contributing to their chemopreventive and therapeutic effects. Phytochemicals represent a valuable resource for developing novel cancer prevention and treatment strategies; their actions on molecular mechanisms and cell signaling pathways underscore their potential in cancer prevention and combat. Further research is warranted to translate these findings into clinical applications, optimizing phytochemical-based interventions for cancer management.