Neeraj Srivastava, M.H. Khan, G. Singh, B. Kumar, A. Jackson, K. Singh, N. Biswas
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引用次数: 0
摘要
氧化应激(OS)对男性生育能力的影响很大,因为它会将生育能力降到很低的水平。公牛睾丸受到的各种损伤,如暴露于毒素、X 射线和环境化学物质、污染物或特定的身体疾病(精索静脉曲张),都可能导致氧化应激,进而反映在精子健康上。自由基引起的损伤可能是活性氧或氮物种造成的。缓解此类 OS 的措施包括采取预防措施抑制自由基的产生,或添加补充剂事后抵消其负面影响。由于自由基的有害影响已得到充分证实,因此需要对精液中自由基的存在及其对精子的影响进行精确评估,以制定抵消操作系统的策略。本综述简要介绍了OS的病因、抗击OS的方法以及对各种可用测定方法的比较分析。
Causes, Ameliorative Measures and Assays to Estimate Testicular Oxidative Stress in Bulls: A Review
Effect of oxidative-stress (OS) on male fertility is much as it reduces fertility to a substantial low level. In bulls, a variety of testicular insults, such as exposure to toxins, X-ray and environmental chemicals, pollutants or specific physical ailments (varicocele) can result in OS which is then reflected in the spermatozoa health. The free-radicals induced damage can be either due to reactive oxygen or nitrogen species. The measures to alleviate such OS include either preventive measures to suppress the production of free-radicals or addition of supplements to counteract the negative effect post-facto. Since detrimental effect of free-radicals is well documented estimation of its presence in semen and effect on spermatozoa need to be carried out precisely to chalk out a strategy to counterbalance the OS. This review briefly touches upon aetiology, methods of combating OS and comparative analysis of various available determinative assays.