二十二碳六烯酸与妊娠:关于改善母体和胎儿健康相关性的系统回顾和元分析

IF 3.4 3区 医学 Q2 NUTRITION & DIETETICS Nutrition Research Pub Date : 2024-08-01 DOI:10.1016/j.nutres.2024.06.008
Kiran Bilgundi , Gollapalle Lakshminarayanashastry Viswanatha , Kowshik Muttur Purushottam , Jeena John , Akshatha P. Kamath , Anoop Kishore , Pawan Ganesh Nayak , Krishnadas Nandakumar
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引用次数: 0

摘要

本研究旨在通过系统综述和荟萃分析,探讨产前补充二十二碳六烯酸(DHA)对妊娠结局的影响。我们假设,产前通过补充剂摄入 DHA 将改善妊娠结局。截至 2022 年 11 月,我们使用 PubMed、EMBASE 和 Google Scholar 等在线数据库进行了详细的文献检索,以确定与安慰剂/对照组相比,母亲在怀孕后半期摄入 DHA 补充剂的随机对照试验(RCT)。根据纳入和排除标准,共纳入了 9 项随机对照试验,涉及 5710 名受试者。这项荟萃分析表明,补充 DHA(450-800 毫克/天)与婴儿出生体重显著增加有关(逆方差 [IV]:101.71 [57.36-146.06],95% CI,P = .00001, I2 = 0%),与安慰剂相比,低出生体重儿(LBW)更少(曼特尔-海恩泽尔 [M-H]: 0.53 [0.33-0.86], 95% CI, P = .01, I2 = 72%),早产儿(PTB)更少,但无统计学意义(M-H: -0.02 [-0.04 to 0.00], 95% CI, P = .07, I2 = 0%)。然而,与安慰剂相比,补充 DHA 对妊娠期长度没有影响(IV:-2.26 [-9.64 to 5.12],95% CI,P = .55,I2 = 100%)。总之,这项荟萃分析的结果表明,产前补充 DHA(450-800 毫克/天)可降低早产风险并增加婴儿出生体重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Docosahexaenoic Acid and Pregnancy: A Systematic Review and Meta-Analysis of the Association with Improved Maternal and Fetal Health

This study aimed to investigate the effects of prenatal docosahexaenoic acid (DHA) supplementation on pregnancy outcomes through a systematic review and meta-analysis. We hypothesized that prenatal DHA intake through supplements will improve pregnancy outcomes. Detailed literature search was performed using online databases such as PubMed, EMBASE, and Google Scholar till November 2022, to identify the randomized controlled trials (RCT) with maternal intake of DHA supplementation during the latter half of pregnancy compared to the placebo/control. Based on the inclusion and exclusion criteria, nine RCTs involving 5710 subjects were included. This meta-analysis showed that DHA supplementation (450-800 mg/day) was associated with a significantly higher birth weight of infants (Inverse variance [IV]: 101.71 [57.36-146.06] at 95% CI, P = .00001, I2 = 0%), and fewer low birth weights (LBWs) (Mantel–Haenszel [M–H]: 0.53 [0.33-0.86] at 95% CI, P = .01, I2 = 72%), with lesser but statistically insignificant pre-term births (PTB) (M–H: -0.02 [-0.04 to 0.00] at 95% CI, P = .07, I2 = 0%) compared to the placebo. However, the DHA supplementation has no effect on gestational length (IV: -2.26 [-9.64 to 5.12] at 95% CI, P = .55, I2 = 100%) compared to the placebo. In conclusion, the outcomes of this meta-analysis showed that prenatal DHA supplementation (450-800 mg/day) may reduce the risk of preterm births and increase infant birth weight.

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来源期刊
Nutrition Research
Nutrition Research 医学-营养学
CiteScore
7.60
自引率
2.20%
发文量
107
审稿时长
58 days
期刊介绍: Nutrition Research publishes original research articles, communications, and reviews on basic and applied nutrition. The mission of Nutrition Research is to serve as the journal for global communication of nutrition and life sciences research on diet and health. The field of nutrition sciences includes, but is not limited to, the study of nutrients during growth, reproduction, aging, health, and disease. Articles covering basic and applied research on all aspects of nutrition sciences are encouraged, including: nutritional biochemistry and metabolism; metabolomics, nutrient gene interactions; nutrient requirements for health; nutrition and disease; digestion and absorption; nutritional anthropology; epidemiology; the influence of socioeconomic and cultural factors on nutrition of the individual and the community; the impact of nutrient intake on disease response and behavior; the consequences of nutritional deficiency on growth and development, endocrine and nervous systems, and immunity; nutrition and gut microbiota; food intolerance and allergy; nutrient drug interactions; nutrition and aging; nutrition and cancer; obesity; diabetes; and intervention programs.
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