Angélica Graça , Sara Bom , Ana M. Martins, Helena M. Ribeiro, Joana Marto
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引用次数: 0
摘要
三维(3D)打印是一种创新的制造方法,有望彻底改变外用和透皮剂型。如今,与市场上的其他三维打印技术相比,基于蒸馏罐的光聚合(VP)三维打印技术具有更高的打印效率和多功能性。然而,这些技术在制药领域的全面应用还存在一些局限性,例如缺乏一系列用于局部和透皮应用的生物相容性材料。这篇综述文章探讨了各种基于 VP 的 3D 打印技术,并讨论了采用这种技术的意义。我们首先详细介绍了打印过程,重点是现有的商业材料和不同作者提出的实验室自制树脂。我们还回顾了该领域的最新研究,主要集中在基于微针阵列的透皮装置的制造上。未来,3D 打印机制造商有望投资改造打印设备,以便同时打印不同的树脂和/或化合物类型,这将为个性化治疗方法开辟新的领域。
Vat-based photopolymerization 3D printing: From materials to topical and transdermal applications
Three-dimensional (3D) printing is an innovative manufacturing method with the potential to revolutionize topical and transdermal dosage forms. Nowadays, it is established that Vat-based photopolymerization (VP) 3D printing technologies offer superior printing efficiency and versatility compared to other 3D printing technologies available on the market. However, there are some limitations that impair their full application in pharmaceutical contexts, such as the lack of a range of biocompatible materials for topical and transdermal applications. This review article explores all types of VP-based 3D printing and discusses the relevance of implementing this kind of technology. We start with a detailed description of the printing process, focusing on the commercial materials available and lab-made resins proposed by different authors. We also review recent studies in this field, which mainly focus on the fabrication of transdermal devices based on microneedle arrays. In the future, it is expected that the manufacturers of 3D printers invest in modifications to the printing apparatus to allow the simultaneous printing of different resins and/or compound types, which will open frontiers to the personalization of treatment approaches.
期刊介绍:
The Asian Journal of Pharmaceutical Sciences (AJPS) serves as the official journal of the Asian Federation for Pharmaceutical Sciences (AFPS). Recognized by the Science Citation Index Expanded (SCIE), AJPS offers a platform for the reporting of advancements, production methodologies, technologies, initiatives, and the practical application of scientific knowledge in the field of pharmaceutics. The journal covers a wide range of topics including but not limited to controlled drug release systems, drug targeting, physical pharmacy, pharmacodynamics, pharmacokinetics, pharmacogenomics, biopharmaceutics, drug and prodrug design, pharmaceutical analysis, drug stability, quality control, pharmaceutical engineering, and material sciences.