以吲哚和异汀类或芳基醛为原料,在三氟化硫铟(III)催化下简单高效地一步法合成取代的 3,3-二芳基吲哚和双(吲哚-3-基)甲烷

IF 1.7 4区 化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-07-15 DOI:10.1055/a-2351-7008
Narra Laxmana Rao, Kolakaluri Chaguru Swamy, Mohan Lakshmi Punna Rao Alapati, Vemulapalli Vandana
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引用次数: 0

摘要

研究发现,三酸铟(III)是一种高效的金属催化剂,可用于取代吲哚与各种异汀或芳基醛在乙腈溶剂中发生亲电取代反应,从而在室温下以高产率分别得到相应的 3,3-二芳基吲哚或双(吲哚-3-基)甲烷。这种新方法具有实验简单、转化率高、收率好甚至极好、反应时间短和操作步骤简单等显著特点。
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An Indium(III) Triflate Catalyzed Simple and Efficient One-Pot Synthesis of Substituted 3,3-Diaryloxindoles and Bis(indol-3-yl) methanes from Indoles and Isatins or Aryl Aldehydes

Indium(III) triflate was found to be an efficient metal catalyst for the electrophilic substitution reaction of substituted indoles with various isatins or aryl aldehydes in acetonitrile solvent to afford the corresponding 3,3-diaryloxindoles or bis(indol-3-yl)methanes, respectively, in high yields at room temperature. This new procedure has remarkable features such as experimental simplicity, high conversions, good to excellent yields, short reaction times, and simple workup procedures

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来源期刊
Synlett
Synlett 化学-有机化学
CiteScore
3.40
自引率
5.00%
发文量
369
审稿时长
1 months
期刊介绍: SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.
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