用于诊断眼部和眼眶黑色素瘤的新型黑色素靶向 18F-PFPN 正电子发射断层成像。

IF 4.4 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Korean Journal of Radiology Pub Date : 2024-08-01 Epub Date: 2024-07-10 DOI:10.3348/kjr.2024.0243
Yiyan Wang, Xinghua Wang, Jie Zhang, Xiao Zhang, Yang Cheng, Fagang Jiang
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引用次数: 0

摘要

目的:18F-N-(2-(二乙基氨基)乙基)-5-(2-(2-(2-氟乙氧基)乙氧基)乙氧基)吡啶酰胺(18F-PFPN)是一种新型正电子发射断层扫描(PET)探针,专为黑色素设计。本研究旨在评估 18F-PFPN 在眼部或眼眶黑色素瘤患者中的诊断可行性:回顾性研究了三名经病理确诊的眼部或眼眶黑色素瘤患者(一名男性,两名女性;年龄 41-59 岁)。每位患者都接受了18F-PFPN和18F-氟脱氧葡萄糖(18F-FDG)正电子发射计算机断层扫描。比较了18F-PFPN和18F-FDG PET成像的病灶最大标准化摄取值(SUVmax)和背景组织造成的干扰。此外,还研究了葡萄膜和视网膜固有色素对结果解读的影响。每位患者的对侧无瘤眼作为对照:所有原发性肿瘤(3/3)均通过 18F-PFPN PET 检测到,而只有两个原发性肿瘤通过 18F-FDG PET 检测到。在每个病灶中,18F-PFPN 的 SUVmax 是 18F-FDG 的 2.6 至 8.3 倍。关于 PET 成像的质量,18F-FDG PET 在大脑和眼周组织中的生理性摄取限制了肿瘤的成像。然而,18F-PFPN PET 将这种干扰降至最低。值得注意的是,葡萄膜和视网膜中的固有色素不会导致18F-PFPN的异常浓度,因为在健康的对侧眼没有检测到18F-PFPN的异常摄取:结论:与 18F-FDG 相比,18F-PFPN 对眼部和眼眶黑色素瘤的检出率更高,且受周围组织的干扰极小。结论:与 18F-FDG 相比,18F-PFPN 对眼部和眼眶黑色素瘤的检出率更高,且对周围组织的干扰极小,这表明 18F-PFPN 是一种很有前途的临床诊断工具,可用于区分眼部和眼眶黑色素瘤中的恶性黑色素瘤和良性色素沉着。
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A Novel Melanin-Targeted 18F-PFPN Positron Emission Tomography Imaging for Diagnosing Ocular and Orbital Melanoma.

Objective: 18F-N-(2-(Diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy) picolinamide (18F-PFPN) is a novel positron emission tomography (PET) probe designed to specifically targets melanin. This study aimed to evaluate the diagnostic feasibility of 18F-PFPN in patients with ocular or orbital melanoma.

Materials and methods: Three patients with pathologically confirmed ocular or orbital melanoma (one male, two females; age 41-59 years) were retrospectively reviewed. Each patient underwent comprehensive 18F-PFPN and 18F-fluorodeoxyglucose (18F-FDG) PET scans. The maximum standardized uptake value (SUVmax) of the lesion and the interference caused by background tissue were compared between 18F-PFPN and 18F-FDG PET imaging. In addition, the effect of intrinsic pigments in the uvea and retina on the interpretation of the results was examined. The contralateral non-tumorous eye of each patient served as a control.

Results: All primary tumors (3/3) were detected using 18F-PFPN PET, while only two primary tumors were detected using 18F-FDG PET. Within each lesion, the SUVmax of 18F-PFPN was 2.6 to 8.3 times higher than that of 18F-FDG. Regarding the quality of PET imaging, the physiological uptake of 18F-FDG PET in the brain and periocular tissues limited the imaging of tumors. However, 18F-PFPN PET minimized this interference. Notably, intrinsic pigments in the uvea and retina did not cause abnormal concentrations of 18F-PFPN, as no anomalous uptake of 18F-PFPN was detected in the healthy contralateral eyes.

Conclusion: Compared to 18F-FDG, 18F-PFPN demonstrated higher detection rates for ocular and orbital melanomas with minimal interference from surrounding tissues. This suggests that 18F-PFPN could be a promising clinical diagnostic tool for distinguishing malignant melanoma from benign pigmentation in ocular and orbital melanomas.

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来源期刊
Korean Journal of Radiology
Korean Journal of Radiology 医学-核医学
CiteScore
10.60
自引率
12.50%
发文量
141
审稿时长
1.3 months
期刊介绍: The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences. A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge. World''s outstanding radiologists from many countries are serving as editorial board of our journal.
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