Chunmiao Liang, Qinghua Sun, Jiali Li, Bing Ji, Weiming Wu, Fukai Zhang, Yuguo Chen, Cong Wang
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引用次数: 0
摘要
目的:近年来,基于人工智能的心电图(ECG)方法被大量应用于心肌梗死(MI)。然而,如何通过对静态和动态特征的联合分析来实现准确、可解释的心肌梗死检测,还没有得到全面解决。本文提出了一种联合分析静态和动态特征的简化集合树方法,以解决 MI 检测中的这一问题。首先,在提取经典静态特征的基础上,通过动态学习对心电图的内在动态进行建模,从而提取动态特征。其次,设计了一种两阶段特征选择策略,以识别少数重要特征,这些特征可替代用于构建集合树的原始变量。这种方法通过选择重要的静态和动态特征来增强判别能力。随后,本文通过引入堆叠集合方案来修改集合树简化算法,提出了一种名为 StackTree 的可解释分类方法。原始集合树中具有代表性的规则被选为中间训练数据,用于重新训练一棵性能接近源集合模型的决策树。采用这种方案,可以全面解决 MI 检测的高精度和可解释性问题。我们使用 PTB 和临床数据库评估了我们的方法在检测 MI 方面的有效性。结果表明,我们的算法优于基于单一类型特征的传统方法。此外,在 PTB 数据库的患者间框架下,该算法的准确率达到了 97.1%,与传统的随机森林算法不相上下。此外,使用临床数据库验证了在 PTB 上训练的特征子集,结果准确率达到 84.5%。所选的重要特征表明,静态和动态信息在 MI 检测中都起着至关重要的作用。最重要的是,所提出的方法以易于理解的可视化方式提供了清晰的内部工作原理。
An interpretable ensemble trees method with joint analysis of static and dynamic features for myocardial infarction detection.
Objective.In recent years, artificial intelligence-based electrocardiogram (ECG) methods have been massively applied to myocardial infarction (MI). However, the joint analysis of static and dynamic features to achieve accurate and interpretable MI detection has not been comprehensively addressed.Approach.This paper proposes a simplified ensemble tree method with a joint analysis of static and dynamic features to solve this issue for MI detection. Initially, the dynamic features are extracted by modeling the intrinsic dynamics of ECG via dynamic learning in addition to extracting classical static features. Secondly, a two-stage feature selection strategy is designed to identify a few significant features, which substitute the original variables that are employed in constructing the ensemble tree. This approach enhances the discriminative ability by selecting significant static and dynamic features. Subsequently, this paper presents an interpretable classification method named StackTree by introducing a stacked ensemble scheme to modify the ensemble tree simplification algorithm. The representative rules of the raw ensemble trees are selected as the intermediate training data that is used to retrain a decision tree with performance close to that of the source ensemble model. Using this scheme, the significant precision and interpretability of MI detection are thus comprehensively addressed.Main results.The effectiveness of our method in detecting MI is evaluated using the Physikalisch-Technische Bundesanstalt (PTB) and clinical database. The findings suggest that our algorithm outperforms the traditional methods based on a single type of feature. Additionally, it is comparable to the conventional random forest, achieving 97.1% accuracy under the inter-patient framework on the PTB database. Furthermore, feature subsets trained on PTB are validated using the clinical database, resulting in an accuracy of 84.5%. The chosen important features demonstrate that both static and dynamic information have crucial roles in MI detection. Crucially, the proposed method provides clear internal workings in an easy-to-understand visual manner.
期刊介绍:
Physiological Measurement publishes papers about the quantitative assessment and visualization of physiological function in clinical research and practice, with an emphasis on the development of new methods of measurement and their validation.
Papers are published on topics including:
applied physiology in illness and health
electrical bioimpedance, optical and acoustic measurement techniques
advanced methods of time series and other data analysis
biomedical and clinical engineering
in-patient and ambulatory monitoring
point-of-care technologies
novel clinical measurements of cardiovascular, neurological, and musculoskeletal systems.
measurements in molecular, cellular and organ physiology and electrophysiology
physiological modeling and simulation
novel biomedical sensors, instruments, devices and systems
measurement standards and guidelines.