双侧正中神经刺激和高频振荡揭示了初级感觉皮层的半球间抑制作用

IF 3.7 3区 医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2024-06-29 DOI:10.1016/j.clinph.2024.06.011
Davide Norata , Gabriella Musumeci , Antonio Todisco , Alessandro Cruciani , Francesco Motolese , Fioravante Capone , Simona Lattanzi , Federico Ranieri , Vincenzo Di Lazzaro , Fabio Pilato
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引用次数: 0

摘要

方法 我们记录了 15 名右手健康受试者左顶叶皮层的体感诱发电位(SEPs)。我们对受试者进行了双侧正中神经刺激,同侧刺激与对侧刺激的时间间隔为 5、10、20 或 40 毫秒。我们根据每个人的 N20 潜伏期调整这些间隔。作为 S1 兴奋性的测量指标,我们分析了每种情况下 N20 的振幅和高频振荡(HFO)爆发的面积。结论研究结果表明,初级躯体感觉区之间存在半球间相互作用,支持触觉信息存在跨胼胝体传递。意义这项研究为初级感觉区之间的半球间联系提供了宝贵的见解,强调了半球间相互作用在躯体感觉处理中的潜在作用。
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Bilateral median nerve stimulation and High-Frequency Oscillations unveil interhemispheric inhibition of primary sensory cortex

Objective

This study aimed at investigating the effect of median nerve stimulation on ipsilateral cortical potentials evoked by contralateral median nerve electrical stimulation.

Methods

We recorded somatosensory-evoked potentials (SEPs) from the left parietal cortex in 15 right-handed, healthy subjects. We administered bilateral median nerve stimulation, with the ipsilateral stimulation preceding the stimulation on the contralateral by intervals of 5, 10, 20, or 40 ms. We adjusted these intervals based on each individual’s N20 latency. As a measure of S1 excitability, the amplitude of the N20 and the area of the High Frequency Oscillation (HFO) burst were analyzed for each condition.

Results

The results revealed significant inhibition of N20 amplitude by ipsilateral median nerve stimulation at interstimulus intervals (ISIs) between 5 and 40 ms. Late HFO burst was suppressed at short ISIs of 5 and 10 ms, pointing to a transcallosal inhibitory effect on S1 intracortical circuits.

Conclusions

Findings suggest interhemispheric interaction between the primary somatosensory areas, supporting the existence of transcallosal transfer of tactile information.

Significance

This study provides valuable insights into the interhemispheric connections between primary sensory areas and underscore the potential role of interhemispheric interactions in somatosensory processing.

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来源期刊
Clinical Neurophysiology
Clinical Neurophysiology 医学-临床神经学
CiteScore
8.70
自引率
6.40%
发文量
932
审稿时长
59 days
期刊介绍: As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.
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