自门控径向自由呼吸肝脏磁共振弹性成像:在 3 T 下评估儿童的技术性能。

IF 3.3 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of Magnetic Resonance Imaging Pub Date : 2024-07-22 DOI:10.1002/jmri.29541
Sevgi Gokce Kafali, Bradley D Bolster, Shu-Fu Shih, Timoteo I Delgado, Vibhas Deshpande, Xiaodong Zhong, Timothy R Adamos, Shahnaz Ghahremani, Kara L Calkins, Holden H Wu
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引用次数: 0

摘要

背景:传统的肝脏磁共振弹性成像(MRE)需要屏气(BH)以避免运动伪影,这对儿童来说具有挑战性。目的:与传统的BH-MRE相比,将四张切片的FB-MRE扫描时间缩短至4分钟,并研究自门控(SG)运动补偿对FB-MRE LS量化的影响,包括一致性、疗程内可重复性和技术质量:研究类型:前瞻性:26名无纤维化的儿童(中位年龄:12.9岁,15名女性):3T;直角坐标梯度回波(GRE)BH-MRE,研究应用径向GRE FB-MRE:在不移动工作台或改变参与者位置的情况下,对参与者进行两次扫描以测量重复性。在数字置信度≥90%的肝脏区域测量 LS。技术质量通过可测量的肝脏面积(%)进行检验:BH-MRE和FB-MRE之间LS的一致性采用Bland-Altman分析法进行评估,SG接受率分别为40%、60%、80%和100%。使用受试者内变异系数(wCV)评估 LS 的可重复性。采用 Kruskal-Wallis 和 Wilcoxon 符号秩检验来检验 LS 和可测量肝脏面积的差异。P 结果:含 60% SG 的 FB-MRE 与 BH-MRE 的一致性最接近(平均差异为 0.00 kPa)。LS 范围为 1.70 至 1.83 kPa,不同 SG 率的 BH-MRE 和 FB-MRE 之间无显著差异(P = 0.52)。所有测试方法都能得出可重复的 LS 值,wCV 为 4.4% 至 6.5%。FB-MRE 可测量肝脏面积的中位数(32%-45%)小于 BH-MRE(91%-93%)(P 数据结论:与 BH-MRE 相比,带有 60% SG 的 FB-MRE 可对儿童 LS 进行量化,且两者的一致性和可重复性相当。
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Self-Gated Radial Free-Breathing Liver MR Elastography: Assessment of Technical Performance in Children at 3 T.

Background: Conventional liver magnetic resonance elastography (MRE) requires breath-holding (BH) to avoid motion artifacts, which is challenging for children. While radial free-breathing (FB)-MRE is an alternative for quantifying liver stiffness (LS), previous methods had limitations of long scan times, acquiring two slices in 5 minutes, and not resolving motion during reconstruction.

Purpose: To reduce FB-MRE scan time to 4 minutes for four slices and to investigate the impact of self-gated (SG) motion compensation on FB-MRE LS quantification in terms of agreement, intrasession repeatability, and technical quality compared to conventional BH-MRE.

Study type: Prospective.

Population: Twenty-six children without fibrosis (median age: 12.9 years, 15 females).

Field strength/sequence: 3 T; Cartesian gradient-echo (GRE) BH-MRE, research application radial GRE FB-MRE.

Assessment: Participants were scanned twice to measure repeatability, without moving the table or changing the participants' position. LS was measured in areas of the liver with numerical confidence ≥90%. Technical quality was examined using measurable liver area (%).

Statistical tests: Agreement of LS between BH-MRE and FB-MRE was evaluated using Bland-Altman analysis for SG acceptance rates of 40%, 60%, 80%, and 100%. LS repeatability was assessed using within-subject coefficient of variation (wCV). The differences in LS and measurable liver area were examined using Kruskal-Wallis and Wilcoxon signed-rank tests. P < 0.05 was considered significant.

Results: FB-MRE with 60% SG achieved the closest agreement with BH-MRE (mean difference 0.00 kPa). The LS ranged from 1.70 to 1.83 kPa with no significant differences between BH-MRE and FB-MRE with varying SG rates (P = 0.52). All tested methods produced repeatable LS with wCV from 4.4% to 6.5%. The median measurable liver area was smaller for FB-MRE (32%-45%) than that for BH-MRE (91%-93%) (P < 0.05).

Data conclusion: FB-MRE with 60% SG can quantify LS with close agreement and comparable repeatability with respect to BH-MRE in children.

Level of evidence: 2 TECHNICAL EFFICACY: Stage 1.

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来源期刊
CiteScore
9.70
自引率
6.80%
发文量
494
审稿时长
2 months
期刊介绍: The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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