Sevgi Gokce Kafali, Bradley D Bolster, Shu-Fu Shih, Timoteo I Delgado, Vibhas Deshpande, Xiaodong Zhong, Timothy R Adamos, Shahnaz Ghahremani, Kara L Calkins, Holden H Wu
{"title":"自门控径向自由呼吸肝脏磁共振弹性成像：在 3 T 下评估儿童的技术性能。","authors":"Sevgi Gokce Kafali, Bradley D Bolster, Shu-Fu Shih, Timoteo I Delgado, Vibhas Deshpande, Xiaodong Zhong, Timothy R Adamos, Shahnaz Ghahremani, Kara L Calkins, Holden H Wu","doi":"10.1002/jmri.29541","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Conventional liver magnetic resonance elastography (MRE) requires breath-holding (BH) to avoid motion artifacts, which is challenging for children. While radial free-breathing (FB)-MRE is an alternative for quantifying liver stiffness (LS), previous methods had limitations of long scan times, acquiring two slices in 5 minutes, and not resolving motion during reconstruction.</p><p><strong>Purpose: </strong>To reduce FB-MRE scan time to 4 minutes for four slices and to investigate the impact of self-gated (SG) motion compensation on FB-MRE LS quantification in terms of agreement, intrasession repeatability, and technical quality compared to conventional BH-MRE.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Twenty-six children without fibrosis (median age: 12.9 years, 15 females).</p><p><strong>Field strength/sequence: </strong>3 T; Cartesian gradient-echo (GRE) BH-MRE, research application radial GRE FB-MRE.</p><p><strong>Assessment: </strong>Participants were scanned twice to measure repeatability, without moving the table or changing the participants' position. LS was measured in areas of the liver with numerical confidence ≥90%. Technical quality was examined using measurable liver area (%).</p><p><strong>Statistical tests: </strong>Agreement of LS between BH-MRE and FB-MRE was evaluated using Bland-Altman analysis for SG acceptance rates of 40%, 60%, 80%, and 100%. LS repeatability was assessed using within-subject coefficient of variation (wCV). The differences in LS and measurable liver area were examined using Kruskal-Wallis and Wilcoxon signed-rank tests. P < 0.05 was considered significant.</p><p><strong>Results: </strong>FB-MRE with 60% SG achieved the closest agreement with BH-MRE (mean difference 0.00 kPa). The LS ranged from 1.70 to 1.83 kPa with no significant differences between BH-MRE and FB-MRE with varying SG rates (P = 0.52). All tested methods produced repeatable LS with wCV from 4.4% to 6.5%. The median measurable liver area was smaller for FB-MRE (32%-45%) than that for BH-MRE (91%-93%) (P < 0.05).</p><p><strong>Data conclusion: </strong>FB-MRE with 60% SG can quantify LS with close agreement and comparable repeatability with respect to BH-MRE in children.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 1.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Self-Gated Radial Free-Breathing Liver MR Elastography: Assessment of Technical Performance in Children at 3 T.\",\"authors\":\"Sevgi Gokce Kafali, Bradley D Bolster, Shu-Fu Shih, Timoteo I Delgado, Vibhas Deshpande, Xiaodong Zhong, Timothy R Adamos, Shahnaz Ghahremani, Kara L Calkins, Holden H Wu\",\"doi\":\"10.1002/jmri.29541\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Conventional liver magnetic resonance elastography (MRE) requires breath-holding (BH) to avoid motion artifacts, which is challenging for children. While radial free-breathing (FB)-MRE is an alternative for quantifying liver stiffness (LS), previous methods had limitations of long scan times, acquiring two slices in 5 minutes, and not resolving motion during reconstruction.</p><p><strong>Purpose: </strong>To reduce FB-MRE scan time to 4 minutes for four slices and to investigate the impact of self-gated (SG) motion compensation on FB-MRE LS quantification in terms of agreement, intrasession repeatability, and technical quality compared to conventional BH-MRE.</p><p><strong>Study type: </strong>Prospective.</p><p><strong>Population: </strong>Twenty-six children without fibrosis (median age: 12.9 years, 15 females).</p><p><strong>Field strength/sequence: </strong>3 T; Cartesian gradient-echo (GRE) BH-MRE, research application radial GRE FB-MRE.</p><p><strong>Assessment: </strong>Participants were scanned twice to measure repeatability, without moving the table or changing the participants' position. LS was measured in areas of the liver with numerical confidence ≥90%. Technical quality was examined using measurable liver area (%).</p><p><strong>Statistical tests: </strong>Agreement of LS between BH-MRE and FB-MRE was evaluated using Bland-Altman analysis for SG acceptance rates of 40%, 60%, 80%, and 100%. LS repeatability was assessed using within-subject coefficient of variation (wCV). The differences in LS and measurable liver area were examined using Kruskal-Wallis and Wilcoxon signed-rank tests. P < 0.05 was considered significant.</p><p><strong>Results: </strong>FB-MRE with 60% SG achieved the closest agreement with BH-MRE (mean difference 0.00 kPa). The LS ranged from 1.70 to 1.83 kPa with no significant differences between BH-MRE and FB-MRE with varying SG rates (P = 0.52). All tested methods produced repeatable LS with wCV from 4.4% to 6.5%. The median measurable liver area was smaller for FB-MRE (32%-45%) than that for BH-MRE (91%-93%) (P < 0.05).</p><p><strong>Data conclusion: </strong>FB-MRE with 60% SG can quantify LS with close agreement and comparable repeatability with respect to BH-MRE in children.</p><p><strong>Level of evidence: </strong>2 TECHNICAL EFFICACY: Stage 1.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2024-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jmri.29541\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jmri.29541","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
Self-Gated Radial Free-Breathing Liver MR Elastography: Assessment of Technical Performance in Children at 3 T.
Background: Conventional liver magnetic resonance elastography (MRE) requires breath-holding (BH) to avoid motion artifacts, which is challenging for children. While radial free-breathing (FB)-MRE is an alternative for quantifying liver stiffness (LS), previous methods had limitations of long scan times, acquiring two slices in 5 minutes, and not resolving motion during reconstruction.
Purpose: To reduce FB-MRE scan time to 4 minutes for four slices and to investigate the impact of self-gated (SG) motion compensation on FB-MRE LS quantification in terms of agreement, intrasession repeatability, and technical quality compared to conventional BH-MRE.
Study type: Prospective.
Population: Twenty-six children without fibrosis (median age: 12.9 years, 15 females).
Field strength/sequence: 3 T; Cartesian gradient-echo (GRE) BH-MRE, research application radial GRE FB-MRE.
Assessment: Participants were scanned twice to measure repeatability, without moving the table or changing the participants' position. LS was measured in areas of the liver with numerical confidence ≥90%. Technical quality was examined using measurable liver area (%).
Statistical tests: Agreement of LS between BH-MRE and FB-MRE was evaluated using Bland-Altman analysis for SG acceptance rates of 40%, 60%, 80%, and 100%. LS repeatability was assessed using within-subject coefficient of variation (wCV). The differences in LS and measurable liver area were examined using Kruskal-Wallis and Wilcoxon signed-rank tests. P < 0.05 was considered significant.
Results: FB-MRE with 60% SG achieved the closest agreement with BH-MRE (mean difference 0.00 kPa). The LS ranged from 1.70 to 1.83 kPa with no significant differences between BH-MRE and FB-MRE with varying SG rates (P = 0.52). All tested methods produced repeatable LS with wCV from 4.4% to 6.5%. The median measurable liver area was smaller for FB-MRE (32%-45%) than that for BH-MRE (91%-93%) (P < 0.05).
Data conclusion: FB-MRE with 60% SG can quantify LS with close agreement and comparable repeatability with respect to BH-MRE in children.
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