利用肽载体提高大麻二酚的水溶性。

IF 1.3 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Turkish Journal of Chemistry Pub Date : 2024-02-16 eCollection Date: 2024-01-01 DOI:10.55730/1300-0527.3655

Melek Parlak Khalily

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引用次数: 0

摘要

大麻二酚（CBD）是一种存在于大麻（Cannabis sativa）中的非精神类大麻素，是一种非常有前途的候选药物，具有许多不同的功效，如镇静、抗炎、抗氧化和神经保护特性。然而，由于 CBD 缺乏水溶性和生物利用度相对较低，其治疗用途受到了阻碍。迄今为止，已有多种载体用于解决 CBD 和其他高亲脂性药物的溶解性问题。然而，以自组装多肽纳米结构为载体来改善 CBD 的水溶性还没有被使用过。本研究证明，自组装肽胶束是封装 CBD 的有效载体，与 CBD 本身相比，其水溶性提高了 2000 倍。

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Improving the water solubility of cannabidiol using a peptide carrier.

Cannabidiol (CBD), nonpsychotropic cannabinoid found in Cannabis sativa, is a very promising drug candidate offering many differential effects such as sedative, antiinflammatory, antioxidant, and neuroprotective properties. Nevertheless, the therapeutic use of CBD is hindered by its lack of water solubility and relatively low bioavailability. Various carriers have been used to address the solubility issues of CBD and other highly lipophilic drugs so far. However, self-assembled peptide nanostructures as carrier have not been used to improve the water solubility of CBD yet. In this study, a self-assembling peptide micelle was demonstrated to be an effective vehicle for encapsulation of CBD and increased its aqueous solubility up to 2000-fold compared to CBD itself.

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来源期刊

Turkish Journal of Chemistry 化学-工程：化工

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： The Turkish Journal of Chemistry is a bimonthly multidisciplinary journal published by the Scientific and Technological Research Council of Turkey (TÜBİTAK). The journal is dedicated to dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, polymeric, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences especially in chemical engineering where molecular aspects are key to the findings. The journal accepts English-language original manuscripts and contribution is open to researchers of all nationalities. The journal publishes refereed original papers, reviews, letters to editor and issues devoted to special fields. All manuscripts are peer-reviewed and electronic processing ensures accurate reproduction of text and data, plus publication times as short as possible.