评估调谐元件镇痛贴片对接受卵巢切除术的狗的术后镇痛效果

Chun Chang, Chia-Yun Lu, I-Ying Chen, Hsien-Chi Wang
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摘要

卵巢切除术(OHE)是小动物常见的外科手术,术后疼痛明显。调谐元件缓解贴片(TERPs)是一种含有钛盐的硅胶贴片,据信可通过共振与疼痛相关的离子通道来缓解疼痛。在本实验中,12 只接受 OHE 手术的狗接受了皮下注射罗本昔布(R 组,[配方:见正文])或两片 TERPs(T 组,[配方:见正文])作为术后镇痛,以评估 TERPs 的镇痛效果。结果表明,术后各组之间的生理参数、疼痛评分和机械痛觉阈值(MNTs)无明显差异,这表明 TERPs 在控制接受 OHE 的犬术后疼痛方面的效果与罗苯昔布相当。本研究为 TERPs 的止痛效果提供了证据,但还需要进一步研究以评估其在各种临床情况下的长期安全性和有效性。
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EVALUATION OF THE POSTOPERATIVE ANALGESIC EFFECTS OF TUNING ELEMENT RELIEF PATCHES IN DOGS UNDERGOING OVARIOHYSTERECTOMY
Ovariohysterectomy (OHE) is a common surgical procedure in small animals that causes significant postoperative pain. Tuning Element Relief Patches (TERPs) are silicone patches containing titanium salts, believed to relieve pain by resonating pain-related ion channels. In this experiment, 12 dogs undergoing OHE surgery received subcutaneous robenacoxib (group R, [Formula: see text]) injection or two sheets of TERPs (group T, [Formula: see text]) as postoperative analgesia to assess the analgesic effect of TERPs. The results demonstrated no significant differences in physiological parameters, pain scores and mechanical nociceptive thresholds (MNTs) between groups postoperatively, indicating that the TERPs provide comparable results to robenacoxib in managing postoperative pain in dogs undergoing OHE. While this study provides evidence of the pain-relieving effects of TERPs, further studies are required to evaluate their long-term safety and efficacy in various clinical conditions.
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