结直肠癌或胰腺癌患者恶病质或体重减轻对死亡率造成的负担:系统性文献综述。

IF 9.4 1区 医学 Q1 GERIATRICS & GERONTOLOGY Journal of Cachexia Sarcopenia and Muscle Pub Date : 2024-08-02 DOI:10.1002/jcsm.13510
Richard F. Dunne, Jeffrey Crawford, Karen E. Smoyer, Thomas D. McRae, Michelle I. Rossulek, James H. Revkin, Lisa C. Tarasenko, Philip D. Bonomi
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引用次数: 0

摘要

癌症相关恶病质是一种多因素消瘦性疾病,其特征是厌食、无意中体重减轻(骨骼肌质量下降,伴有或不伴有脂肪质量下降)、进行性功能障碍和预后不良。本系统性文献综述(SLR)研究了近期文献中结直肠癌或胰腺癌患者恶病质与生存之间的关系。SLR遵循PRISMA指南进行。对 Embase® 和 PubMed 进行了检索,以确定 2016 年 1 月 1 日至 2021 年 10 月 10 日期间发表的、报道成人癌症患者生存率和恶病质或有恶病质风险(根据国际共识 (IC) 诊断标准或任何体重减轻的更广泛定义)的英文文章。纳入的文献均为对≥100 名结直肠癌或胰腺癌患者进行的研究。有 13 篇针对结直肠癌患者和 13 篇针对胰腺癌患者的研究符合资格标准。纳入的研究均为观察性研究,主要来自欧洲和美国。11项研究(42%)采用IC标准报告了恶病质,15项研究(58%)报告了体重减轻。通过多变量分析(n = 23)或单变量分析(n = 3)评估了不同研究中生存率与恶病质或体重减轻之间的关系,并在每项研究中评估了多个体重减轻类别。在采用多变量分析的 23 项研究中,有 16 项研究的至少一个体重减轻类别与恶病质/体重减轻相关,而在采用单变量分析的 3 项研究中,有 1 项研究(33%)的至少一个体重减轻类别与较差的存活率相关。在 17 项有显著相关性的研究中,9 项针对结直肠癌患者,8 项针对胰腺癌患者。在近三分之二的研究中,痛风或体重减轻与结直肠癌或胰腺癌患者生存率明显降低有关。不同研究和研究内部对体重减轻的分类各不相同(评估了多个类别),这可能是造成差异的原因之一。不过,在结直肠癌或胰腺癌患者的临床实践中,对恶病质的认识和对体重变化的常规评估有助于为预后提供信息并影响早期疾病管理策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The mortality burden of cachexia or weight loss in patients with colorectal or pancreatic cancer: A systematic literature review

Cancer-associated cachexia is a multifactorial wasting disorder characterized by anorexia, unintentional weight loss (skeletal muscle mass with or without loss of fat mass), progressive functional impairment, and poor prognosis. This systematic literature review (SLR) examined the relationship between cachexia and survival in patients with colorectal or pancreatic cancer in recent literature. The SLR was conducted following PRISMA guidelines. Embase® and PubMed were searched to identify articles published in English between 1 January 2016 and 10 October 2021 reporting survival in adults with cancer and cachexia or at risk of cachexia, defined by international consensus (IC) diagnostic criteria or a broader definition of any weight loss. Included publications were studies in ≥100 patients with colorectal or pancreatic cancer. Thirteen publications in patients with colorectal cancer and 13 with pancreatic cancer met eligibility criteria. Included studies were observational and primarily from Europe and the United States. Eleven studies (42%) reported cachexia using IC criteria and 15 (58%) reported any weight loss. An association between survival and cachexia or weight loss was assessed across studies using multivariate (n = 23) or univariate (n = 3) analyses and within each study across multiple weight loss categories. Cachexia/weight loss was associated with a statistically significantly poorer survival in at least one weight loss category in 16 of 23 studies that used multivariate analyses and in 1 of 3 studies (33%) that used univariate analyses. Of the 17 studies demonstrating a significant association, 9 were in patients with colorectal cancer and 8 were in patients with pancreatic cancer. Cachexia or weight loss was associated with significantly poorer survival in patients with colorectal or pancreatic cancer in nearly two-thirds of the studies. The classification of weight loss varied across and within studies (multiple categories were evaluated) and may have contributed to variability. Nonetheless, awareness of cachexia and routine assessment of weight change in clinical practice in patients with colorectal or pancreatic cancer could help inform prognosis and influence early disease management strategies.

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来源期刊
Journal of Cachexia Sarcopenia and Muscle
Journal of Cachexia Sarcopenia and Muscle MEDICINE, GENERAL & INTERNAL-
CiteScore
13.30
自引率
12.40%
发文量
234
审稿时长
16 weeks
期刊介绍: The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials related to cachexia and sarcopenia, as well as body composition and its physiological and pathophysiological changes across the lifespan and in response to various illnesses from all fields of life sciences. The journal aims to provide a reliable resource for professionals interested in related research or involved in the clinical care of affected patients, such as those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis.
期刊最新文献
Issue Information Neuromuscular impairment at different stages of human sarcopenia The impact of mobility limitations on geriatric rehabilitation outcomes: Positive effects of resistance exercise training (RESORT) Artificial neural network inference analysis identified novel genes and gene interactions associated with skeletal muscle aging Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5’-monophosphate (AMP)-activated protein kinase α1 via ubiquitin specific peptidase 5
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