标准:人体肠芯片。

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-08-05 DOI:10.1186/s13619-024-00198-7
Haitao Liu, Yaqing Wang, Xu Zhang, Min Zhang, Peng Wang, Jing Shang, Zhongqiang Li, Likun Gong, Jiabin Guo, Wei Sun, Jingbo Pi, Xianliang Li, Wei Ding, Dianbing Wang, Zhongyu Li, Jingzhong Zhang, Lan Wang, Xingchao Geng, Ruifu Yang, Pingkun Zhou, Wanjin Tang, Xian'en Zhang, Chunying Chen, Shengli Yang, Jianhua Qin
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引用次数: 0

摘要

片上器官是一种微生理系统,可以复制人体器官的关键功能,加速疾病建模、药物开发和精准医疗等生命科学领域的创新。然而,由于在定义、结构设计、细胞来源、模型构建和功能验证等方面缺乏标准,片上器官的广泛转化应用仍面临挑战。"片上器官2024年4月29日,由中国生物技术学会专家共同商定并发布的《芯片上器官:肠道》是我国首个芯片上人体肠道的团体标准。该标准规定了建立芯片人体肠道模型的范围、术语、定义、技术要求、检测方法和质量控制。该团体标准的发布将指导机构建立、接受和执行适当的实用协议,并加速转化应用中的芯片肠道的国际标准化。
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Standard: human intestine-on-a-chip.

Organs-on-chips are microphysiological systems that allow to replicate the key functions of human organs and accelerate the innovation in life sciences including disease modeling, drug development, and precision medicine. However, due to the lack of standards in their definition, structural design, cell source, model construction, and functional validation, a wide range of translational application of organs-on-chips remains a challenging. "Organs-on-chips: Intestine" is the first group standard on human intestine-on-a-chip in China, jointly agreed and released by the experts from the Chinese Society of Biotechnology on 29th April 2024. This standard specifies the scope, terminology, definitions, technical requirements, detection methods, and quality control in building the human intestinal model on a chip. The publication of this group standard will guide the institutional establishment, acceptance and execution of proper practical protocols and accelerate the international standardization of intestine-on-a-chip for translational applications.

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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
期刊最新文献
Application and new findings of scRNA-seq and ST-seq in prostate cancer. Beyond resorption: osteoclasts as drivers of bone formation. Subtype-specific neurons from patient iPSCs display distinct neuropathological features of Alzheimer's disease. Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities. Chromatin remodeling in tissue stem cell fate determination.
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