与人乳头瘤病毒相关的鼻窦癌的形态学谱系。

IF 3.2 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2024-08-05 DOI:10.1007/s12105-024-01670-1

Tarek Abi-Saab, Taja Lozar, Yi Chen, Alex P Tannenbaum, Heather Geye, Menggang Yu, Paul Weisman, Paul M Harari, Randall J Kimple, Paul F Lambert, Ricardo V Lloyd, Rong Hu

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引用次数: 0

摘要

背景：高危人乳头瘤病毒（HR-HPV）感染已逐渐被认为是鼻窦道癌的一个危险因素。然而，由于研究有限以及HPV检测方法在文献中的不一致，人们对HPV相关鼻窦癌的发病率和预后意义还不甚了解。从形态上看，HPV 相关性鼻窦癌包括多种肿瘤。HPV相关鼻窦腺癌尚未见报道。本研究旨在确定与 HPV 相关的鼻窦癌的发病率、形态谱和预后影响：方法：该队列包括 153 例鼻窦癌。构建了组织芯片。进行了P16免疫组化和HR-HPV E6/7原位杂交（ISH）。根据 ISH 检测的阳性结果，癌症被视为与 HPV 相关。结果：28/153（18%）例鼻窦癌与 HPV 相关。HPV相关癌包括26例（93%）鳞状细胞癌和变异型、1例（3.5%）HPV相关多型鼻窦癌和1例（3.5%）腺癌。HPV相关腺癌在形态上与HPV相关宫颈内膜腺癌非常相似。HPV相关癌发生在8名女性（29%）和20名男性（71%）身上，中位年龄为66岁。HPV相关癌主要位于鼻腔。据观察，HPV相关癌患者的总生存期和无进展生存期有改善趋势，但无统计学意义：我们的研究发现了一种新型 HPV 相关鼻窦腺癌亚型，强调了 HPV 相关鼻窦腺癌的广泛形态谱，并支持在病理实践中进行常规 p16 检测，无论肿瘤亚型如何，然后再进行确证性 HR-HPV 检测。这种做法对于研究 HPV 相关鼻窦癌的临床表现至关重要。

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Morphologic Spectrum of HPV-associated Sinonasal Carcinomas.

Background: High-risk human papillomavirus (HR-HPV) infection has been increasingly recognized as a risk factor for sinonasal tract carcinomas. However the prevalence and prognostic significance of HPV-associated sinonasal carcinomas is not well known due to limited studies and inconsistency in HPV testing modalities in literatures. Morphologically, HPV-associated sinonasal carcinomas encompass a diverse group of tumors. HPV-associated sinonasal adenocarcinoma has not been reported. The purpose of this study was to determine the prevalence, morphologic spectrum and prognostic implication of HPV-associated sinonasal carcinomas.

Methods: This cohort included 153 sinonasal carcinomas. Tissue microarrays were constructed. P16 immunohistochemistry and HR-HPV E6/7 in-situ Hybridization (ISH) were performed. Carcinomas were deemed HPV-associated based on a positive ISH testing. Clinicopathologic data was collected.

Results: 28/153 (18%) sinonasal carcinomas were HPV-associated. HPV-associated carcinomas consisted of 26 (93%) squamous cell carcinomas and variants, 1 (3.5%) HPV-related multiphenotypic sinonasal carcinoma and 1 (3.5%) adenocarcinoma. The HPV-associated adenocarcinoma closely resembled HPV-associated endocervical adenocarcinoma morphologically. HPV-associated carcinomas occurred in 8 (29%) women and 20 (71%) men with a median age of 66 years old. HPV-associated carcinomas were predominantly located at nasal cavity. A trend toward improved overall survival and progression free survival in HPV-associated carcinomas patients was observed, yet without statistical significance.

Conclusion: Our study identifies a novel HPV-associated sinonasal adenocarcinoma subtype, highlights the broad morphologic spectrum of HPV-associated sinonasal carcinomas, and supports routine p16 testing during pathology practice regardless of tumor subtype followed by a confirmatory HR-HPV testing. This practice is critical for studying the clinical behavior of HPV-associated sinonasal carcinomas.

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.