维生素 D 相关生物标志物与男性和女性高血压及肾素-血管紧张素系统的关系

IF 3.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE American Journal of Hypertension Pub Date : 2024-11-15 DOI:10.1093/ajh/hpae103
Lu Wang, Nancy R Cook, JoAnn E Manson, J Michael Gaziano, Julie E Buring, Howard D Sesso
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引用次数: 0

摘要

背景:维生素 D 可通过下调肾素-血管紧张素系统来预防高血压的发生。然而,评估维生素 D 相关生物标志物与高血压之间相互关系的流行病学研究却很少:我们在一项巢式病例对照研究中考察了维生素 D 相关生物标志物与高血压风险之间的前瞻性关联。在妇女健康研究(WHS)和医生健康研究(PHS)II中,随机各选取了500名高血压病例和500名年龄与种族匹配的对照者。测量了基线血浆 25(OH)-维生素 D [25(OH)D]、甲状旁腺激素(PTH)和总肾素的浓度:结果:在对照组中,25(OH)D 和 PTH 呈反向相关,但两者均与总肾素无关。在粗略模型中,25(OH)D 的五分位数增加与女性患高血压的风险降低呈相关趋势,相对风险和 95% CI 分别为 1.00、1.24(0.84-1.83)、0.82(0.53-1.25)、0.75(0.48-1.16)和 0.81(0.52-1.27)(p,趋势:0.07)。对体重指数和其他高血压风险因素进行调整后,这种关联消失了(第 5 个五分位数的 RR:1.03)。在男性中未发现相关性。基线 PTH 和 25(OH)D 与 PTH 的比率与女性或男性的高血压风险无关。当将男性和女性纳入同一模型时,维生素 D 不足(定义为 25(OH)D 结论:25(OH)D 不足与高血压风险无关:我们的研究发现,基线血浆 25(OH)D 或 PTH 与中老年男性和女性的高血压风险或总肾素浓度无关。
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Associations of Vitamin D-Related Biomarkers With Hypertension and the Renin-Angiotensin System in Men and Women.

Background: Vitamin D may prevent the development of hypertension through down-regulation of renin-angiotensin system. However, epidemiologic studies assessing the interrelation of vitamin D-related biomarkers with hypertension are sparse.

Methods: We examined the prospective associations between vitamin D-related biomarkers and the risk of hypertension in a nested case-control study. In each of the Women's Health Study (WHS) and Physicians' Health Study (PHS) II, 500 incident hypertension cases and 500 age and race-matched controls were randomly selected. Baseline plasma 25(OH)-vitamin D [25(OH)D], parathyroid hormone (PTH), and total renin concentrations were measured.

Results: Among controls, 25(OH)D and PTH were inversely correlated, but neither was correlated with total renin. In the crude model, there was a trend of association between increasing quintiles of 25(OH)D and lower risk of hypertension in women, with relative risks and 95% CIs of 1.00, 1.24 (0.84-1.83), 0.82 (0.53-1.25), 0.75 (0.48-1.16), and 0.81 (0.52-1.27) (P, trend: .07). Adjustment for body mass index and other hypertension risk factors eliminated this association (relative risk of 5th quintile: 1.03). No associations were found in men. Baseline PTH and ratio of 25(OH)D to PTH were not associated with the risk of hypertension in women or men. When men and women were included in the same model, vitamin D insufficiency (defined as 25(OH)D <20 ng/mL) also was not associated with an increased risk of hypertension. No interactions were found across subgroups.

Conclusions: Our study found no association of baseline plasma 25(OH)D or PTH with the risk of hypertension or total renin concentration in middle-aged and older men and women.

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来源期刊
American Journal of Hypertension
American Journal of Hypertension 医学-外周血管病
CiteScore
6.90
自引率
6.20%
发文量
144
审稿时长
3-8 weeks
期刊介绍: The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.
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