具有抑菌消炎、清除 ROS 和制氧特性的含纳米酶水凝胶促进糖尿病感染伤口的愈合。

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2024-08-09 DOI:10.1002/jbm.b.35458
Le-Ping Chen, Xin-Yu Wang, Ming-Jin Ren, Yuan Wang, Jia-Meng Zhao, Ti-Ti Qiang, Lin-Yi Dong, Xian-Hua Wang
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引用次数: 0

摘要

细菌感染已对皮肤伤口构成严重威胁,尤其是对伤口愈合困难的糖尿病患者而言。然而,众所周知,伤口或细菌感染会产生过量的活性氧(ROS),而缺氧可能会进一步阻碍伤口愈合和慢性伤口的发展。在本研究中,通过将聚乙烯醇(PVA)和海藻酸钠(SA)与负载银铂混合纳米粒子(GO@Ag-Pt)的氧化石墨烯(GO)交联,开发了一种清除 ROS 和抑制细菌的多功能水凝胶。负载了 GO@Ag-Pt 的 PVA/SA 水凝胶具有清除不同类型的 ROS、产生 O2 和体外杀灭广谱细菌的能力。与银纳米粒子(AgNps)相比,银铂混合纳米粒子能显著提高对大肠杆菌和金黄色葡萄球菌的抗菌能力。负载了 GO@Ag-Pt 的水凝胶能有效治疗金黄色葡萄球菌引起的感染,从而在炎症阶段明显促进伤口愈合。水凝胶疗法大大降低了 ROS 水平,缓解了炎症水平。值得注意的是,我们的 ROS 清除抗菌水凝胶可用于有效治疗各种类型的伤口,包括细菌感染的难以愈合的糖尿病伤口。因此,本研究提出了一种基于 ROS 清除和抑菌水凝胶的有效策略,用于各种慢性伤口愈合。
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Promoting the healing of infected diabetic wound by nanozyme-containing hydrogel with anti-bacterial inflammation suppressing, ROS-scavenging and oxygen-generating properties

Bacterial infections already pose a significant threat to skin wounds, especially in diabetic patients who have difficulty healing wounds. However, wound or bacterial infections are known to produce excess reactive oxygen species (ROS), and hypoxia may further hinder wound healing and the development of chronic wounds. In this study, a multifunctional hydrogel for ROS scavenging and bacterial inhibition was developed by cross-linking polyvinyl alcohol (PVA) and sodium alginate (SA) with graphene oxide (GO) loaded with silver-platinum hybrid nanoparticles (GO@Ag-Pt). The PVA/SA hydrogel loaded with GO@Ag-Pt exhibited the ability to scavenge different types of ROS, generate O2, and kill a broad spectrum of bacteria in vitro. The silver-platinum hybrid nanoparticles significantly increased the antibacterial ability against Escherichia coli and Staphylococcus aureus compared with silver nanoparticles (AgNps). GO@Ag-Pt loaded hydrogel was effective in treating infections caused by S.aureus, thereby significantly promoting wound healing during the inflammatory phase. Hydrogel therapy significantly reduced the level of ROS and alleviated inflammation levels. Notably, our ROS-scavenging, antibacterial hydrogels can be used to effectively treat various types of wounds, including difficult-to-heal diabetic wounds with bacterial infections. Thus, this study proposes an effective strategy for various chronic wound healing based on ROS clearance and bacteriostatic hydrogels.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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