Ru(II)-Catalyzed C8 Alkenylation of Isoquinolones with Allyl Alcohol

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-08-09 DOI:10.1002/ajoc.202400407

Manisha, Tamanna Sharma, Upendra Sharma

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引用次数: 0

摘要

本研究开发了一种简单的 Ru(II) 催化方案，用于将异喹诺酮与容易获得的烯丙基醇进行烯丙基化反应，生成含醛的异喹诺酮。由于使用了碳酸二甲酯等绿色溶剂，该方法对环境友好。实验研究支持了所提出的机理。为了展示当前方法的应用，对反应进行了放大。

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Ru(II)‐Catalyzed C8 Alkenylation of Isoquinolones with Allyl Alcohol

A simple Ru(II)‐catalyzed protocol for the alkenylation of isoquinolones with readily accessible allyl alcohols to generate aldehyde bearing isoquinolones has been developed. The use of green solvent like dimethyl carbonate makes this method environment‐friendly. Experimental studies were carried out to support the proposed mechanism. The reaction was scaled up to showcase the application of the current method.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.