Yang Yu, Lan Ding, Ren-Nai Yang, Liang-Ping Zha, Ju-Tao Wang, Shuang-Ying Gui
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Phenylpropanoids with Anti-Inflammatory Effects from the Roots of Platycodon grandiflorus
Two new phenylpropanoids, plagnans (1) and plaganoid (2), along with five known phenylpropanoids, including an enantiomeric mixture (compound 3) were isolated from the roots of Platycodon grandiflorus. Meanwhile, their structures were elucidated by analyzing the spectroscopic data, including NMR, HR-ESI-MS, ECD (ICD), and X-ray analysis. Although all isolates were evaluated for their anti-inflammatory activities, and of them exhibited moderate activities, with IC50 values of around 27.5 μM.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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