{"title":"早年体重指数与六种心血管疾病的风险：孟德尔随机研究。","authors":"Bojun Zhou, Lianghao Zhu, Xia Du, Hua Meng","doi":"10.1111/ijpo.13157","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Observational studies consistently indicate an association between early-life body mass index (BMI) and several cardiovascular diseases (CVDs). However, the causal relationship remains uncertain. The primary objective of this study was to assess the causal relationship between early-life BMI and six types of CVDs using the Mendelian Randomization (MR) approach.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The dataset for this study was derived from large-scale, summary-level Genome-Wide Association Studies. Specifically, the following datasets we used, early-life BMI (<i>n</i> = 61 111, age = 2–10), heart failure (HF) dataset (<i>n</i> = 977 323), atrial fibrillation (AF) dataset (<i>n</i> = 1 030 836), coronary artery disease (CAD) dataset (<i>n</i> = 184 305), peripheral artery disease (PAD) dataset (<i>n</i> = 243 060), deep venous thrombosis (DVT) dataset (<i>n</i> = 1 500 861) and myocardial infarction (MI) dataset (<i>n</i> = 638 000). Multiple MR methods were utilized to evaluate the causal relationship between exposure and outcomes, accompanied by sensitivity analysis.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Early-life BMI positively correlates with the risk of developing the six distinct CVDs included in this study. Specifically, elevated BMI during childhood is associated with a 31.9% risk for HF (Odds ratio [OR] = 1.319, 95% CI [1.160 to 1.499], <i>p</i> = 2.33 × 10<sup>−5</sup>), an 18.3% risk for AF (R = 1.183, 95% CI [1.088 to 1.287], <i>p</i> = 8.22 × 10<sup>−5</sup>), an 14.8% risk for CAD (OR = 1.148, 95% CI [1.028 to 1.283], <i>p</i> = 1.47 × 10<sup>−2</sup>), a 40.5% risk for PAD (OR = 1.405, 95% CI [1.233 to 1.600], <i>p</i> = 3.10 × 10<sup>−7</sup>) and 12.0% risk for MI (OR = 1.120, 95% CI [1.017 to 1.234], <i>p</i> = 2.18 × 10<sup>−2</sup>). Interestingly, the risk for deep venous thrombosis only increased by 0.5% (OR = 1.005, 95% CI [1.001 to 1.008], <i>p</i> = 2.13 × 10<sup>−3</sup>).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Genetically inferred early-life BMI is significantly associated with six distinct CVDs. This indicates that elevated early-life BMI is a significant risk factor for multiple cardiovascular disorders.</p>\n </section>\n </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"19 10","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Early-life body mass index and the risk of six cardiovascular diseases: A Mendelian Randomization study\",\"authors\":\"Bojun Zhou, Lianghao Zhu, Xia Du, Hua Meng\",\"doi\":\"10.1111/ijpo.13157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Observational studies consistently indicate an association between early-life body mass index (BMI) and several cardiovascular diseases (CVDs). However, the causal relationship remains uncertain. The primary objective of this study was to assess the causal relationship between early-life BMI and six types of CVDs using the Mendelian Randomization (MR) approach.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The dataset for this study was derived from large-scale, summary-level Genome-Wide Association Studies. Specifically, the following datasets we used, early-life BMI (<i>n</i> = 61 111, age = 2–10), heart failure (HF) dataset (<i>n</i> = 977 323), atrial fibrillation (AF) dataset (<i>n</i> = 1 030 836), coronary artery disease (CAD) dataset (<i>n</i> = 184 305), peripheral artery disease (PAD) dataset (<i>n</i> = 243 060), deep venous thrombosis (DVT) dataset (<i>n</i> = 1 500 861) and myocardial infarction (MI) dataset (<i>n</i> = 638 000). Multiple MR methods were utilized to evaluate the causal relationship between exposure and outcomes, accompanied by sensitivity analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Early-life BMI positively correlates with the risk of developing the six distinct CVDs included in this study. Specifically, elevated BMI during childhood is associated with a 31.9% risk for HF (Odds ratio [OR] = 1.319, 95% CI [1.160 to 1.499], <i>p</i> = 2.33 × 10<sup>−5</sup>), an 18.3% risk for AF (R = 1.183, 95% CI [1.088 to 1.287], <i>p</i> = 8.22 × 10<sup>−5</sup>), an 14.8% risk for CAD (OR = 1.148, 95% CI [1.028 to 1.283], <i>p</i> = 1.47 × 10<sup>−2</sup>), a 40.5% risk for PAD (OR = 1.405, 95% CI [1.233 to 1.600], <i>p</i> = 3.10 × 10<sup>−7</sup>) and 12.0% risk for MI (OR = 1.120, 95% CI [1.017 to 1.234], <i>p</i> = 2.18 × 10<sup>−2</sup>). Interestingly, the risk for deep venous thrombosis only increased by 0.5% (OR = 1.005, 95% CI [1.001 to 1.008], <i>p</i> = 2.13 × 10<sup>−3</sup>).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Genetically inferred early-life BMI is significantly associated with six distinct CVDs. This indicates that elevated early-life BMI is a significant risk factor for multiple cardiovascular disorders.</p>\\n </section>\\n </div>\",\"PeriodicalId\":217,\"journal\":{\"name\":\"Pediatric Obesity\",\"volume\":\"19 10\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13157\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13157","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
Early-life body mass index and the risk of six cardiovascular diseases: A Mendelian Randomization study
Background
Observational studies consistently indicate an association between early-life body mass index (BMI) and several cardiovascular diseases (CVDs). However, the causal relationship remains uncertain. The primary objective of this study was to assess the causal relationship between early-life BMI and six types of CVDs using the Mendelian Randomization (MR) approach.
Methods
The dataset for this study was derived from large-scale, summary-level Genome-Wide Association Studies. Specifically, the following datasets we used, early-life BMI (n = 61 111, age = 2–10), heart failure (HF) dataset (n = 977 323), atrial fibrillation (AF) dataset (n = 1 030 836), coronary artery disease (CAD) dataset (n = 184 305), peripheral artery disease (PAD) dataset (n = 243 060), deep venous thrombosis (DVT) dataset (n = 1 500 861) and myocardial infarction (MI) dataset (n = 638 000). Multiple MR methods were utilized to evaluate the causal relationship between exposure and outcomes, accompanied by sensitivity analysis.
Results
Early-life BMI positively correlates with the risk of developing the six distinct CVDs included in this study. Specifically, elevated BMI during childhood is associated with a 31.9% risk for HF (Odds ratio [OR] = 1.319, 95% CI [1.160 to 1.499], p = 2.33 × 10−5), an 18.3% risk for AF (R = 1.183, 95% CI [1.088 to 1.287], p = 8.22 × 10−5), an 14.8% risk for CAD (OR = 1.148, 95% CI [1.028 to 1.283], p = 1.47 × 10−2), a 40.5% risk for PAD (OR = 1.405, 95% CI [1.233 to 1.600], p = 3.10 × 10−7) and 12.0% risk for MI (OR = 1.120, 95% CI [1.017 to 1.234], p = 2.18 × 10−2). Interestingly, the risk for deep venous thrombosis only increased by 0.5% (OR = 1.005, 95% CI [1.001 to 1.008], p = 2.13 × 10−3).
Conclusion
Genetically inferred early-life BMI is significantly associated with six distinct CVDs. This indicates that elevated early-life BMI is a significant risk factor for multiple cardiovascular disorders.
期刊介绍：
Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large.
Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following:
Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes
Metabolic consequences of child and adolescent obesity
Epidemiological and population-based studies of child and adolescent overweight and obesity
Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition
Clinical management of children and adolescents with obesity including studies of treatment and prevention
Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment
Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity
Nutrition security and the "double burden" of obesity and malnutrition
Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents
Community and public health measures to prevent overweight and obesity in children and adolescents.
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