中国男性职业苯暴露与癌症风险:上海男性健康研究报告》。

IF 3.7 3区 医学 Q2 ONCOLOGY Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-11-01 DOI:10.1158/1055-9965.EPI-24-0325
Douglas DeMoulin, Hui Cai, Roel Vermeulen, Wei Zheng, Loren Lipworth, Xiao-Ou Shu
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引用次数: 0

摘要

背景:苯暴露与白血病和其他癌症风险的增加有关;然而,关于后者的流行病学证据并不一致,而且很少对吸烟和饮酒造成的混杂因素进行调整:方法:我们在一个由 61,377 名 40-74 岁男性组成的人群队列中调查了职业苯暴露与白血病、淋巴瘤、骨髓瘤、肺癌、胃癌、肝癌和肾癌风险的相关性。工业卫生学家专门为研究人群构建了一个工作-接触矩阵,用于推算所有工作中累积的苯接触量。在对潜在混杂因素进行调整后,通过 Cox 回归估算出苯与癌症风险关联的调整后危险比 (aHR) 和 95% 置信区间 (CI):在 15 年的随访中,共发现 1,145 例肺癌、656 例胃癌、445 例肝癌、243 例肾癌、100 例白血病、124 例淋巴瘤和 46 例骨髓瘤病例。苯暴露量大于 550 毫克/立方米与白血病(aHR=2.3,95%CI=1.1-4.5)、肺癌(aHR=1.2,95%CI=1.0-1.6)和胃癌(aHR=1.4,95%CI=1.0-1.9)风险增加有关;苯暴露与癌症诊断年龄提前有关。苯与白血病和胃癌的关系呈线性剂量反应模式(Plinear=0.016 和 0.023),而苯与肺癌的关系在暴露水平较高时明显(Pnon-linear=0.027)。饮酒改变了苯与白血病的关系(饮酒者的 HR=3.0,95%CI=1.1-8.3;不饮酒者的 aHR=0.9,95%CI=0.4-2.0,Pinteraction=0.047):结论:苯暴露与白血病、胃癌和肺癌风险的增加有关。饮酒可能会改变苯与白血病的关系,但估计值并不精确:我们的研究提供了更多证据,证明苯暴露会增加白血病以外的癌症风险,这些信息对于政策制定者制定减轻苯暴露工人癌症风险的计划非常重要。
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Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men's Health Study.

Background: Benzene exposure has been associated with increased risk of leukemia and other cancers; however, epidemiologic evidence is inconsistent for the latter, and confounding from smoking and alcohol was rarely adjusted.

Methods: We investigated associations between occupational benzene exposure and risk of leukemia, lymphoma, myeloma, and lung, stomach, liver, and kidney cancers in a population-based cohort of 61,377 men, ages 40 to 74 years. A job-exposure matrix, constructed by industrial hygienists specifically for the study population, was used to derive cumulative benzene exposure from all jobs held. Cox regressions were performed to estimate adjusted HRs (aHR) and 95% confidence intervals (CI) for benzene-cancer risk associations with adjustment for potential confounders.

Results: Over 15 years of follow-up, 1,145 lung cancer, 656 stomach cancer, 445 liver cancer, 243 kidney cancer, 100 leukemia, 124 lymphoma, and 46 myeloma cases were identified. Benzene exposure >550 mg/m3 was associated with an increased risk of leukemia (aHR = 2.3; 95% CI, 1.1-4.5), lung cancer (aHR = 1.2; 95% CI, 1.0-1.6), and stomach cancer (aHR = 1.4; 95% CI, 1.0-1.9); benzene exposure was associated with early cancer diagnosis age. The benzene-leukemia and benzene-stomach cancer associations followed a linear dose-response pattern (Plinear = 0.016 and 0.023), whereas the benzene-lung cancer association was evident at higher exposure levels (Pnonlinear = 0.027). Alcohol consumption modified the benzene-leukemia association (aHR = 3.0; 95% CI, 1.1-8.3 for drinkers and aHR = 0.9; 95% CI, 0.4-2.0 for nondrinkers, Pinteraction = 0.047).

Conclusions: Benzene exposure was associated with an increased risk of leukemia, stomach cancer, and lung cancer. Alcohol consumption may modify the benzene-leukemia association, although estimates are imprecise.

Impact: Our study provides additional evidence that benzene exposure increases cancer risk beyond leukemia, information important for policymakers to develop programs to mitigate cancer risk among benzene-exposed workers.

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来源期刊
Cancer Epidemiology Biomarkers & Prevention
Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.50
自引率
2.60%
发文量
538
审稿时长
1.6 months
期刊介绍: Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
期刊最新文献
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