Oxidase mimicking nanozyme: Classification, catalytic mechanisms and sensing applications

Nanozymes are a type of nanomaterials that mimics natural enzymes with biocatalytic functions. Oxidase is a kind of oxidoreductase which oxidizes hydrogen donor substrates in the presence of molecular oxygen. Recently, there have been many reports on various nanomaterials exhibiting oxidase-mimicking activity, which currently became one of the most extensively studied enzymatic property with broad applications. Considering the significant advances and superior prospects of oxidase mimics, this review categorizes oxidase mimicking nanozymes based on their substrates and brief introduction of their syntheses. Further their sensing applications along with the possible catalytic mechanisms are systematically and comprehensively overviewed and discussed. Eventually, the possible opportunities and challenges in the future to explore oxidase mimics for applications in sensing or analytical chemistry are prospected.