Toll 样受体 4--一种多功能病毒识别受体。

IF 14 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Microbiology Pub Date : 2024-08-22 DOI:10.1016/j.tim.2024.07.001
Elina Gerber-Tichet, Fabien P Blanchet, Karim Majzoub, Eric J Kremer
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引用次数: 0

摘要

自从果蝇的 Toll 受体及其哺乳动物的 Toll 样受体(TLRs)被首次描述以来,许多基础研究和应用研究都在探索它们作为病原体相关分子模式(PAMPs)传感器的关键作用。在人类的十种 TLRs 中,TLR4 尤以其检测革兰氏阴性细菌细胞壁成分脂多糖(LPS)的能力而闻名。除了其典型功能外,TLR4 还是一种多功能病毒传感器。本综述介绍了发现 TLR4 的背景,以及这一知识如何为通过遗传、生化、结构和免疫学方法研究 TLR4 在抗病毒反应中的各种作用奠定了基础。这些进展加深了人们对 TLR4 分子功能的理解,TLR4 能够协调专业抗原递呈细胞(APCs)的多节点控制,从而启动适当的、受调控的抗病毒免疫反应。
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Toll-like receptor 4 - a multifunctional virus recognition receptor.

Since the initial description of Toll receptors in Drosophila and their mammalian counterparts Toll-like receptors (TLRs), numerous fundamental and applied studies have explored their crucial role as sensors of pathogen-associated molecular patterns (PAMPs). Among the ten human TLRs, TLR4 is particularly well known for its ability to detect lipopolysaccharides (LPS), a component of the Gram-negative bacterial cell wall. In addition to its archetypal functions, TLR4 is also a versatile virus sensor. This review provides a background on the discovery of TLR4 and how this knowledge laid a foundation for characterization of its diverse roles in antiviral responses, examined through genetic, biochemical, structural, and immunological approaches. These advances have led to a deeper understanding of the molecular functions that enable TLR4 to orchestrate multi-nodal control by professional antigen-presenting cells (APCs) to initiate appropriate and regulated antiviral immune responses.

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来源期刊
Trends in Microbiology
Trends in Microbiology 生物-生化与分子生物学
CiteScore
25.30
自引率
0.60%
发文量
193
审稿时长
6-12 weeks
期刊介绍: Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.
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