{"title":"全面的化学-孔-机械耦合对皮下注射建模的重要性","authors":"","doi":"10.1016/j.jmps.2024.105833","DOIUrl":null,"url":null,"abstract":"<div><p>Modeling of subcutaneous injections in soft adipose tissue – a common way to administer pharmaceutical medication – is a challenging multiphysics problem which has recently attracted the attention of the engineering community, as it could help optimize medical devices and treatments. The underlying continuum mechanics of this process is complex and involves finite strain poro-mechanics – where a viscous fluid, containing different charged species, is injected into a porous viscoelastic matrix and absorbed by blood and lymph vessels – as well as electrochemistry, that generates osmotic pressure due to electrical charges attached to the tissue. In this paper, we present a chemo-mechanical model of subcutaneous injections that accounts for the diffusion of electrically charged chemical species – contained in the interstitial fluid – into the tissue, blood and lymph vessels. This work provides the methodology to derive a general theory accounting for the electro-chemo-poro-mechanical couplings in a thermodynamically consistent framework, avoiding phenomenological biases or inconsistencies likely to arise in the derivation of nonlinear theories with many couplings. To motivate its use for the modeling of subcutaneous injections, it is complemented by a simplified, linearized boundary value problem that illustrates the importance of considering these couplings for the prediction of subcutaneous injections key performance indicators.</p></div>","PeriodicalId":17331,"journal":{"name":"Journal of The Mechanics and Physics of Solids","volume":null,"pages":null},"PeriodicalIF":5.0000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The importance of a full chemo-poro-mechanical coupling for the modeling of subcutaneous injections\",\"authors\":\"\",\"doi\":\"10.1016/j.jmps.2024.105833\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Modeling of subcutaneous injections in soft adipose tissue – a common way to administer pharmaceutical medication – is a challenging multiphysics problem which has recently attracted the attention of the engineering community, as it could help optimize medical devices and treatments. The underlying continuum mechanics of this process is complex and involves finite strain poro-mechanics – where a viscous fluid, containing different charged species, is injected into a porous viscoelastic matrix and absorbed by blood and lymph vessels – as well as electrochemistry, that generates osmotic pressure due to electrical charges attached to the tissue. In this paper, we present a chemo-mechanical model of subcutaneous injections that accounts for the diffusion of electrically charged chemical species – contained in the interstitial fluid – into the tissue, blood and lymph vessels. This work provides the methodology to derive a general theory accounting for the electro-chemo-poro-mechanical couplings in a thermodynamically consistent framework, avoiding phenomenological biases or inconsistencies likely to arise in the derivation of nonlinear theories with many couplings. To motivate its use for the modeling of subcutaneous injections, it is complemented by a simplified, linearized boundary value problem that illustrates the importance of considering these couplings for the prediction of subcutaneous injections key performance indicators.</p></div>\",\"PeriodicalId\":17331,\"journal\":{\"name\":\"Journal of The Mechanics and Physics of Solids\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.0000,\"publicationDate\":\"2024-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of The Mechanics and Physics of Solids\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022509624002990\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of The Mechanics and Physics of Solids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022509624002990","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
The importance of a full chemo-poro-mechanical coupling for the modeling of subcutaneous injections
Modeling of subcutaneous injections in soft adipose tissue – a common way to administer pharmaceutical medication – is a challenging multiphysics problem which has recently attracted the attention of the engineering community, as it could help optimize medical devices and treatments. The underlying continuum mechanics of this process is complex and involves finite strain poro-mechanics – where a viscous fluid, containing different charged species, is injected into a porous viscoelastic matrix and absorbed by blood and lymph vessels – as well as electrochemistry, that generates osmotic pressure due to electrical charges attached to the tissue. In this paper, we present a chemo-mechanical model of subcutaneous injections that accounts for the diffusion of electrically charged chemical species – contained in the interstitial fluid – into the tissue, blood and lymph vessels. This work provides the methodology to derive a general theory accounting for the electro-chemo-poro-mechanical couplings in a thermodynamically consistent framework, avoiding phenomenological biases or inconsistencies likely to arise in the derivation of nonlinear theories with many couplings. To motivate its use for the modeling of subcutaneous injections, it is complemented by a simplified, linearized boundary value problem that illustrates the importance of considering these couplings for the prediction of subcutaneous injections key performance indicators.
期刊介绍:
The aim of Journal of The Mechanics and Physics of Solids is to publish research of the highest quality and of lasting significance on the mechanics of solids. The scope is broad, from fundamental concepts in mechanics to the analysis of novel phenomena and applications. Solids are interpreted broadly to include both hard and soft materials as well as natural and synthetic structures. The approach can be theoretical, experimental or computational.This research activity sits within engineering science and the allied areas of applied mathematics, materials science, bio-mechanics, applied physics, and geophysics.
The Journal was founded in 1952 by Rodney Hill, who was its Editor-in-Chief until 1968. The topics of interest to the Journal evolve with developments in the subject but its basic ethos remains the same: to publish research of the highest quality relating to the mechanics of solids. Thus, emphasis is placed on the development of fundamental concepts of mechanics and novel applications of these concepts based on theoretical, experimental or computational approaches, drawing upon the various branches of engineering science and the allied areas within applied mathematics, materials science, structural engineering, applied physics, and geophysics.
The main purpose of the Journal is to foster scientific understanding of the processes of deformation and mechanical failure of all solid materials, both technological and natural, and the connections between these processes and their underlying physical mechanisms. In this sense, the content of the Journal should reflect the current state of the discipline in analysis, experimental observation, and numerical simulation. In the interest of achieving this goal, authors are encouraged to consider the significance of their contributions for the field of mechanics and the implications of their results, in addition to describing the details of their work.