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引用次数: 0
摘要
一些动物和人类研究显示了肠道微生物群的性别差异，但结果并不一致。通讯生物学》（Communications Biology）杂志上的一项研究通过比较青春期前后雌雄小鼠的肠道微生物群，就睾酮和性别对小鼠肠道微生物群的影响提供了新的见解。结果表明，雌雄小鼠的微生物组组成存在差异，这种差异只有在青春期后才能看到。值得注意的是，进入青春期后，雄性小鼠的梭状芽孢杆菌属相对丰度高于雌性小鼠，而雌性小鼠的弧菌属丰度更高，弧菌属与小鼠抑郁和肥胖有关。在探索体内补充睾酮的影响时，研究人员发现睾酮会影响雄性和雌性小鼠的肠道微生物群和代谢组。这些结果表明，青春期后微生物群发生了变化，部分原因是体内性激素（主要是睾酮）水平升高：Moadi, L. et al.7, 880 (2024)
期刊介绍：
LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research.
LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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