{"title":"微生物代谢物影响慢性肾脏病的进展","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01429-9","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 9","pages":"218-218"},"PeriodicalIF":5.9000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microbial metabolite affects CKD progression\",\"authors\":\"Alexandra Le Bras\",\"doi\":\"10.1038/s41684-024-01429-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":17936,\"journal\":{\"name\":\"Lab Animal\",\"volume\":\"53 9\",\"pages\":\"218-218\"},\"PeriodicalIF\":5.9000,\"publicationDate\":\"2024-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lab Animal\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.nature.com/articles/s41684-024-01429-9\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab Animal","FirstCategoryId":"97","ListUrlMain":"https://www.nature.com/articles/s41684-024-01429-9","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
多项研究已经证实，微生物代谢物失调与肥胖和高血压等疾病的进展之间存在联系。然而，肠道微生物组及其代谢在慢性肾脏病（CKD）中的作用在很大程度上仍不为人所知。一项新的研究表明，约翰逊乳杆菌和微生物衍生的吲哚-3-甲醛（IAld）水平的降低在很大程度上导致了大鼠慢性肾脏病的进展。研究人员发现，在腺嘌呤诱导的慢性肾功能衰竭大鼠体内，约翰逊乳杆菌的数量减少，而补充约翰逊乳杆菌能改善动物的肾脏纤维化。同样，研究小组发现，使用单侧输尿管阻塞和5/6肾切除术诱导CKD的大鼠血清中IAld水平降低，而IAld治疗可减轻肾脏病变。结果还表明，IAld可通过改善肠上皮屏障功能和抑制芳基烃受体（AHR）信号通路来防止肾损伤，为治疗CKD提供了新的潜在途径：Miao, H. et al.Target Ther.9, 195 (2024)
期刊介绍：
LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research.
LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
