孟加拉国高致病性禽流感病毒的系统动力学,确定家鸭为扩增宿主库。

IF 8.4 2区 医学 Q1 IMMUNOLOGY Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI:10.1080/22221751.2024.2399268
Ariful Islam, Michelle Wille, Mohammed Ziaur Rahman, Ashleigh F Porter, Mohammed Enayet Hosaain, Mohammad Mahmudul Hassan, Tahmina Shirin, Jonathan H Epstein, Marcel Klaassen
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引用次数: 0

摘要

摘要 高致病性禽流感病毒 H5N1 于 2007 年首次在孟加拉国出现。尽管自 2012 年以来一直在鸡身上使用疫苗来控制高致病性禽流感,但高致病性禽流感 H5Nx 病毒仍继续感染家禽和野鸟,导致家鸦(Corvus splendens)大量死亡。孟加拉国首次出现的高致病性禽流感 H5Nx 病毒属于 2.2.2 支系,2011 年又出现了 2.3.4.2 支系和 2.3.2.1 支系病毒。2012 年实施鸡疫苗接种后,这些病毒大部分被 2.3.2.1a 支系病毒取代,最近又被 2.3.4.4b 和 h 支系病毒取代。在本研究中,我们重建了孟加拉国高致病性禽流感 H5Nx 病毒的系统发育历史,以评估主要宿主物种在孟加拉国高致病性禽流感 H5Nx 病毒的维持和进化中的作用,并揭示受严重影响的乌鸦在病毒流行病学中的作用。高致病性禽流感 H5N1 和 H5N6 病毒在家鸦中引起的流行潮每年冬季都会发生。对 2.3.2.1a 支系的贝叶斯系统动力学分析表明,家鸭、鸡和家鸦之间频繁的双向病毒转换明显偏向于家鸭;家鸭可能是孟加拉国高致病性禽流感 H5Nx 的源头或储库,因为从家鸭到鸡和家鸦的病毒转换次数远远多于其他转换。我们的研究结果表明,尽管接种了疫苗,病毒仍在家禽中传播,乌鸦疫情是一个哨点。疫苗接种策略需要更新,以使用更有效的疫苗,评估疫苗效力,并将疫苗接种范围扩大到家鸭--主要的病毒库。
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Phylodynamics of high pathogenicity avian influenza virus in Bangladesh identifying domestic ducks as the amplifying host reservoir.

High pathogenicity avian influenza (HPAI) virus H5N1 first emerged in Bangladesh in 2007. Despite the use of vaccines in chickens since 2012 to control HPAI, HPAI H5Nx viruses have continued to infect poultry, and wild birds, resulting in notable mass mortalities in house crows (Corvus splendens). The first HPAI H5Nx viruses in Bangladesh belonged to clade 2.2.2, followed by clade 2.3.4.2 and 2.3.2.1 viruses in 2011. After the implementation of chicken vaccination in 2012, these viruses were mostly replaced by clade 2.3.2.1a viruses and more recently clade 2.3.4.4b and h viruses. In this study, we reconstruct the phylogenetic history of HPAI H5Nx viruses in Bangladesh to evaluate the role of major host species in the maintenance and evolution of HPAI H5Nx virus in Bangladesh and reveal the role of heavily impacted crows in virus epidemiology. Epizootic waves caused by HPAI H5N1 and H5N6 viruses amongst house crows occurred annually in winter. Bayesian phylodynamic analysis of clade 2.3.2.1a revealed frequent bidirectional viral transitions between domestic ducks, chickens, and house crows that was markedly skewed towards ducks; domestic ducks might be the source, or reservoir, of HPAI H5Nx in Bangladesh, as the number of viral transitions from ducks to chickens and house crows was by far more numerous than the other transitions. Our results suggest viral circulation in domestic birds despite vaccination, with crow epizootics acting as a sentinel. The vaccination strategy needs to be updated to use more effective vaccinations, assess vaccine efficacy, and extension of vaccination to domestic ducks, the key reservoir.

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来源期刊
Emerging Microbes & Infections
Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY
CiteScore
26.20
自引率
2.30%
发文量
276
审稿时长
20 weeks
期刊介绍: Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.
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