超低频透射超声乳腺成像与 DBT(数字乳腺断层扫描)对比:患者报告结果研究》。

IF 1.8 Q3 HEALTH CARE SCIENCES & SERVICES Patient Related Outcome Measures Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI:10.2147/PROM.S423380
Elaine Iuanow, Emily A Pickup, Bilal Malik, Julie Doehrmann, Fernando A Huyke, Rachel Ducker, John Klock
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引用次数: 0

摘要

目的:在美国,乳腺癌筛查仍然是一项挑战。许多妇女因为检查带来的疼痛、辐射、假阳性结果和额外费用而不做乳房 X 光检查。还有一些可能从年度筛查中获益的妇女由于年龄小和辐射风险而不符合条件。我们假设,一种新型的容积透射式乳腺超声检查--定量透射(QT)扫描--可能会鼓励更多妇女进行年度乳腺癌筛查。评估患者报告结果(PROs)可预测更新、更理想的筛查技术的价值:符合乳腺癌筛查条件的绝经前和绝经后妇女参加了定量透射(QT 扫描)与通过数字乳腺断层合成(DBT)进行的传统乳腺 X 线照相术的前瞻性试验,临床试验.gov NCT03052166。这些妇女填写了调查问卷,以评估她们对 QT 扫描和 DBT 的体验。结果:共有 430 名受试者完成了 PRO 工具的分析。共提出了 36 个问题,其中 34 个问题同时针对 QT 和 DBT,两个问题仅针对 QT 扫描。身体不适、对安全性和低效性的看法、假阳性结果和额外的自付费用被认为是选择不接受乳腺 X 线照相筛查的最大风险(2.1 和 2.9 之间的差异表示平均值和标准差之间存在显著差异,使用 Cohen's d 统计量)。学生 T 检验显示显著性水平为-10。在 17 个配对体验问题中,有 14 个问题观察到 QT 扫描和 DBT 在 PROs 方面存在统计学意义上的重大差异(p 结论:QT扫描和DBT之间的PROs存在显著差异,表明妇女对传统乳腺X光检查和DBT的负面体验明显更多,更不愿意接受乳腺X光筛查。识别PRO差异有助于确定更理想的乳腺癌筛查方式。
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Ultra-Low Frequency Transmitted Ultrasound Breast Imaging vs DBT (Digital Breast Tomosynthesis): A Patient-Reported Outcome Study.

Purpose: Breast cancer screening remains a challenge in the United States. Many women do not get a mammogram because of pain associated with the exam, radiation exposure, false-positive results, and additional costs. Others who may benefit from annual screening do not qualify because of young age and radiation risk. We hypothesize that a novel volumetric transmitted breast ultrasound, Quantitative Transmission (QT) Scan may encourage more women to have annual breast cancer screening. Assessing results from patient-reported outcomes (PROs) may predict the value of newer, more desirable screening technologies.

Participants and methods: Pre- and post-menopausal women who qualified for breast cancer screening were enrolled in a prospective trial of Quantitative Transmission (QT Scan) vs traditional mammography via Digital Breast Tomosynthesis (DBT) Clinical Trials.gov NCT03052166. These women completed questionnaires to assess their experiences with QT Scan and DBT. Associations between QT Scan or DBT and differences in PRO scores were examined.

Results: A total of 430 subjects completed the PRO instrument analyzed. A total of 36 questions were asked, 34 were paired for both QT and DBT and two were asked regarding exclusively the QT Scan. Physical discomfort, perceptions of safety and low efficacy, false-positive results and additional out-of-pocket expenses were concerns identified as highest risk for opting out of screening mammography (differences between 2.1 and 2.9 indicate significant differences between means and standard deviations using the Cohen's d statistic). Student's T-test shows a significance level of <10 -10. Statistically significant differences in PROs between QT Scan and DBT were observed by 14 of the 17 paired experience questions (p<0.001).

Conclusion: Significant differences in PROs were found between QT scan and DBT, indicating women have significantly more negative experiences with traditional mammography via DBT and are less inclined to undergo screening mammography. Identification of PRO differences could be used to help identify a more desirable breast cancer screening modality.

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来源期刊
Patient Related Outcome Measures
Patient Related Outcome Measures HEALTH CARE SCIENCES & SERVICES-
自引率
4.80%
发文量
27
审稿时长
16 weeks
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