{"title":"基于超声诊断平台的超声溶栓过程中的二维时空被动空化成像与评估","authors":"","doi":"10.1016/j.ultsonch.2024.107051","DOIUrl":null,"url":null,"abstract":"<div><p>Acoustic cavitation plays a critical role in various biomedical applications. However, uncontrolled cavitation can lead to undesired damage to healthy tissues. Therefore, real-time monitoring and quantitative evaluation of cavitation dynamics is essential for understanding underlying mechanisms and optimizing ultrasound treatment efficiency and safety. The current research addressed the limitations of traditionally used cavitation detection methods by developing introduced an adaptive time-division multiplexing passive cavitation imaging (PCI) system integrated into a commercial diagnostic ultrasound platform. This new method combined real-time cavitation monitoring with B-mode imaging, allowing for simultaneous visualization of treatment progress and 2D quantitative evaluation of cavitation dosage within targeted area. An improved delay-and-sum (DAS) algorithm, optimized with a minimum variance (MV) beamformer, is utilized to minimize the side lobe effect and improve the axial resolution typically associated with PCI. In additional to visualize and quantitatively assess the cavitation activities generated under varied acoustic pressures and microbubble concentrations, this system was specifically applied to perform 2D cavitation evaluation for ultrasound thrombolysis mediated by different solutions, <em>e.g.</em>, saline, nanodiamond (ND) and nitrogen-annealed nanodiamond (N-AND). This research aims to bridge the gap between laboratory-based research systems and real-time spatiotemporal cavitation evaluation demands in practical uses. Results indicate that this improved 2D cavitation monitoring and evaluation system could offer a useful tool for comprehensive evaluating cavitation-mediated effects (<em>e.g.</em>, ultrasound thrombolysis), providing valuable insights into in-depth understanding of cavitation mechanisms and optimization of cavitation applications.</p></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":null,"pages":null},"PeriodicalIF":8.7000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1350417724002992/pdfft?md5=e2ca50f87d64b80ac5b59eba07821824&pid=1-s2.0-S1350417724002992-main.pdf","citationCount":"0","resultStr":"{\"title\":\"2D spatiotemporal passive cavitation imaging and evaluation during ultrasound thrombolysis based on diagnostic ultrasound platform\",\"authors\":\"\",\"doi\":\"10.1016/j.ultsonch.2024.107051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Acoustic cavitation plays a critical role in various biomedical applications. 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In additional to visualize and quantitatively assess the cavitation activities generated under varied acoustic pressures and microbubble concentrations, this system was specifically applied to perform 2D cavitation evaluation for ultrasound thrombolysis mediated by different solutions, <em>e.g.</em>, saline, nanodiamond (ND) and nitrogen-annealed nanodiamond (N-AND). This research aims to bridge the gap between laboratory-based research systems and real-time spatiotemporal cavitation evaluation demands in practical uses. 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引用次数: 0
摘要
声空化在各种生物医学应用中发挥着至关重要的作用。然而,不受控制的空化会对健康组织造成不必要的损伤。因此,对空化动态进行实时监测和定量评估对于了解其潜在机制、优化超声治疗效率和安全性至关重要。目前的研究针对传统空化检测方法的局限性,开发了一种自适应时分复用被动空化成像(PCI)系统,并将其集成到商用超声诊断平台中。这种新方法将实时空化监测与 B 型成像相结合,可同时观察治疗进展并对目标区域内的空化剂量进行二维定量评估。改进的延迟和(DAS)算法通过最小方差(MV)波束形成器进行优化,最大程度地减少了侧叶效应,提高了通常与 PCI 相关的轴向分辨率。为了对不同声压和微泡浓度下产生的空化活动进行可视化和定量评估,该系统还专门用于对不同溶液(如生理盐水、纳米金刚石(ND)和氮退火纳米金刚石(N-AND))介导的超声溶栓进行二维空化评估。这项研究旨在缩小实验室研究系统与实际应用中实时时空空化评估需求之间的差距。结果表明,这种改进的二维空化监测和评估系统可为全面评估空化介导的效应(如超声溶栓)提供有用的工具,为深入了解空化机制和优化空化应用提供有价值的见解。
2D spatiotemporal passive cavitation imaging and evaluation during ultrasound thrombolysis based on diagnostic ultrasound platform
Acoustic cavitation plays a critical role in various biomedical applications. However, uncontrolled cavitation can lead to undesired damage to healthy tissues. Therefore, real-time monitoring and quantitative evaluation of cavitation dynamics is essential for understanding underlying mechanisms and optimizing ultrasound treatment efficiency and safety. The current research addressed the limitations of traditionally used cavitation detection methods by developing introduced an adaptive time-division multiplexing passive cavitation imaging (PCI) system integrated into a commercial diagnostic ultrasound platform. This new method combined real-time cavitation monitoring with B-mode imaging, allowing for simultaneous visualization of treatment progress and 2D quantitative evaluation of cavitation dosage within targeted area. An improved delay-and-sum (DAS) algorithm, optimized with a minimum variance (MV) beamformer, is utilized to minimize the side lobe effect and improve the axial resolution typically associated with PCI. In additional to visualize and quantitatively assess the cavitation activities generated under varied acoustic pressures and microbubble concentrations, this system was specifically applied to perform 2D cavitation evaluation for ultrasound thrombolysis mediated by different solutions, e.g., saline, nanodiamond (ND) and nitrogen-annealed nanodiamond (N-AND). This research aims to bridge the gap between laboratory-based research systems and real-time spatiotemporal cavitation evaluation demands in practical uses. Results indicate that this improved 2D cavitation monitoring and evaluation system could offer a useful tool for comprehensive evaluating cavitation-mediated effects (e.g., ultrasound thrombolysis), providing valuable insights into in-depth understanding of cavitation mechanisms and optimization of cavitation applications.
期刊介绍:
Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels.
Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.