短暂定植的微生物会导致肠道菌群失调和功能障碍。

IF 7.8 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY npj Biofilms and Microbiomes Pub Date : 2024-09-08 DOI:10.1038/s41522-024-00561-1
Sunjae Lee, Victoria Meslier, Gholamreza Bidkhori, Fernando Garcia-Guevara, Lucie Etienne-Mesmin, Frederick Clasen, Junseok Park, Florian Plaza Oñate, Haizhuang Cai, Emmanuelle Le Chatelier, Nicolas Pons, Marcela Pereira, Maike Seifert, Fredrik Boulund, Lars Engstrand, Doheon Lee, Gordon Proctor, Adil Mardinoglu, Stéphanie Blanquet-Diot, David Moyes, Mathieu Almeida, S Dusko Ehrlich, Mathias Uhlen, Saeed Shoaie
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引用次数: 0

摘要

健康成年人肠道微生物群的物种组成随着时间的推移趋于稳定。在不同因素的影响下,肠道微生物群的不稳定性是导致微生物菌群失调并进而影响宿主生理机能的主要原因。在这里,我们利用来自瑞典纵向队列的元基因组学数据确定了肠道微生物群的稳定性,并发现了两个不同的微生物物种群:持久定植物种(PCS)和短暂定植物种(TCS)。我们从同一瑞典队列的其他时间点生成了肠道元基因组学数据,验证了这一分组的持续性。我们评估了不同地理区域中 PCS/TCS 的存在情况,并观察到它们是全球一致的特征。为了描述 PCS/TCS 的表型,我们对粪便样本进行了生物反应器发酵,并建立了代谢模型。最后,利用慢性病肠道元基因组和其他多组学数据,我们确定了 TCS 在微生物菌群失调中的作用,以及与宿主生理异常变化的联系。
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Transient colonizing microbes promote gut dysbiosis and functional impairment.

Species composition of the healthy adult gut microbiota tends to be stable over time. Destabilization of the gut microbiome under the influence of different factors is the main driver of the microbial dysbiosis and subsequent impacts on host physiology. Here, we used metagenomics data from a Swedish longitudinal cohort, to determine the stability of the gut microbiome and uncovered two distinct microbial species groups; persistent colonizing species (PCS) and transient colonizing species (TCS). We validated the continuation of this grouping, generating gut metagenomics data for additional time points from the same Swedish cohort. We evaluated the existence of PCS/TCS across different geographical regions and observed they are globally conserved features. To characterize PCS/TCS phenotypes, we performed bioreactor fermentation with faecal samples and metabolic modeling. Finally, using chronic disease gut metagenome and other multi-omics data, we identified roles of TCS in microbial dysbiosis and link with abnormal changes to host physiology.

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来源期刊
npj Biofilms and Microbiomes
npj Biofilms and Microbiomes Immunology and Microbiology-Microbiology
CiteScore
12.10
自引率
3.30%
发文量
91
审稿时长
9 weeks
期刊介绍: npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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