使用统计形状和统计外观建模方法评估儿科脊椎尺寸和密度中与年龄相关的性双态性

IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Bone Pub Date : 2024-09-07 DOI:10.1016/j.bone.2024.117251
Natalia M. Castoldi , Dermot O'Rourke , Maria Antico , Vittorio Sansalone , Laura Gregory , Peter Pivonka
{"title":"使用统计形状和统计外观建模方法评估儿科脊椎尺寸和密度中与年龄相关的性双态性","authors":"Natalia M. Castoldi ,&nbsp;Dermot O'Rourke ,&nbsp;Maria Antico ,&nbsp;Vittorio Sansalone ,&nbsp;Laura Gregory ,&nbsp;Peter Pivonka","doi":"10.1016/j.bone.2024.117251","DOIUrl":null,"url":null,"abstract":"<div><p>This work focuses on the growth patterns of the human fourth lumbar vertebra (L4) in a paediatric population, with specific attention to sexual dimorphism. The study aims to understand morphological and density changes in the vertebrae through age-dependent statistical shape and statistical appearance models, which can describe full three-dimensional anatomy. Results show that the main growth patterns are associated with isotropic volumetric vertebral growth, a decrease in the relative size of the vertebral foramen, and an increase in the length of the transverse processes. Moreover, significant sexual dimorphism was demonstrated during puberty. We observe significant age and sex interaction in the anterior vertebral body height (<em>P</em> = 0.005), where females exhibited an earlier increase in rates of vertebral height evolution. Moreover, we also observe an increase in cross-sectional area (CSA) with age (<em>P</em> = 0.020), where the CSA is smaller in females than in males (significant sex effect <em>P</em> = 0.042). Finally, although no significant increase in trabecular bone density with age is observed (<em>P</em> = 0.363), a trend in the statistical appearance model suggests an increase in density with age.</p></div>","PeriodicalId":9301,"journal":{"name":"Bone","volume":"189 ","pages":"Article 117251"},"PeriodicalIF":3.5000,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S8756328224002400/pdfft?md5=326eea364020ae4b2ddeef656abe33d9&pid=1-s2.0-S8756328224002400-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Assessment of age-dependent sexual dimorphism in paediatric vertebral size and density using a statistical shape and statistical appearance modelling approach\",\"authors\":\"Natalia M. Castoldi ,&nbsp;Dermot O'Rourke ,&nbsp;Maria Antico ,&nbsp;Vittorio Sansalone ,&nbsp;Laura Gregory ,&nbsp;Peter Pivonka\",\"doi\":\"10.1016/j.bone.2024.117251\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This work focuses on the growth patterns of the human fourth lumbar vertebra (L4) in a paediatric population, with specific attention to sexual dimorphism. The study aims to understand morphological and density changes in the vertebrae through age-dependent statistical shape and statistical appearance models, which can describe full three-dimensional anatomy. Results show that the main growth patterns are associated with isotropic volumetric vertebral growth, a decrease in the relative size of the vertebral foramen, and an increase in the length of the transverse processes. Moreover, significant sexual dimorphism was demonstrated during puberty. We observe significant age and sex interaction in the anterior vertebral body height (<em>P</em> = 0.005), where females exhibited an earlier increase in rates of vertebral height evolution. Moreover, we also observe an increase in cross-sectional area (CSA) with age (<em>P</em> = 0.020), where the CSA is smaller in females than in males (significant sex effect <em>P</em> = 0.042). Finally, although no significant increase in trabecular bone density with age is observed (<em>P</em> = 0.363), a trend in the statistical appearance model suggests an increase in density with age.</p></div>\",\"PeriodicalId\":9301,\"journal\":{\"name\":\"Bone\",\"volume\":\"189 \",\"pages\":\"Article 117251\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-09-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S8756328224002400/pdfft?md5=326eea364020ae4b2ddeef656abe33d9&pid=1-s2.0-S8756328224002400-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bone\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S8756328224002400\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bone","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S8756328224002400","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

这项研究的重点是人类第四腰椎(L4)在儿科人群中的生长模式,特别关注性别二态性。研究旨在通过与年龄相关的统计形状和统计外观模型来了解椎骨的形态和密度变化,这些模型可以描述完整的三维解剖结构。结果表明,主要的生长模式与各向同性的椎体体积增长、椎孔相对大小的减小以及横突长度的增加有关。此外,青春期还表现出明显的性别二态性。在椎体前部高度方面,我们观察到了明显的年龄和性别交互作用(P = 0.005),其中雌性的椎体高度进化率增长较早。此外,我们还观察到横截面积(CSA)随着年龄的增长而增加(P = 0.020),其中女性的横截面积小于男性(显著性别效应 P = 0.042)。最后,虽然没有观察到骨小梁密度随年龄的增长而明显增加(P = 0.363),但统计外观模型中的趋势表明密度会随着年龄的增长而增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Assessment of age-dependent sexual dimorphism in paediatric vertebral size and density using a statistical shape and statistical appearance modelling approach

This work focuses on the growth patterns of the human fourth lumbar vertebra (L4) in a paediatric population, with specific attention to sexual dimorphism. The study aims to understand morphological and density changes in the vertebrae through age-dependent statistical shape and statistical appearance models, which can describe full three-dimensional anatomy. Results show that the main growth patterns are associated with isotropic volumetric vertebral growth, a decrease in the relative size of the vertebral foramen, and an increase in the length of the transverse processes. Moreover, significant sexual dimorphism was demonstrated during puberty. We observe significant age and sex interaction in the anterior vertebral body height (P = 0.005), where females exhibited an earlier increase in rates of vertebral height evolution. Moreover, we also observe an increase in cross-sectional area (CSA) with age (P = 0.020), where the CSA is smaller in females than in males (significant sex effect P = 0.042). Finally, although no significant increase in trabecular bone density with age is observed (P = 0.363), a trend in the statistical appearance model suggests an increase in density with age.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Bone
Bone 医学-内分泌学与代谢
CiteScore
8.90
自引率
4.90%
发文量
264
审稿时长
30 days
期刊介绍: BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.
期刊最新文献
Three-dimensional cranial suture morphometric changes in young rats during normal growth The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma A NOTCH2 pathogenic variant and HES1 regulate osteoclastogenesis in induced pluripotent stem cells Temporal trends in the burden of musculoskeletal diseases in China from 1990 to 2021 and predictions for 2021 to 2030 Macrophage migration inhibitory factor promotes heterotopic ossification by mediating ROS/HIF-1α positive feedback loop and activating Wnt/β-catenin signaling pathway
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1