使用统计形状和统计外观建模方法评估儿科脊椎尺寸和密度中与年龄相关的性双态性

IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Bone Pub Date : 2024-09-07 DOI:10.1016/j.bone.2024.117251
Natalia M. Castoldi , Dermot O'Rourke , Maria Antico , Vittorio Sansalone , Laura Gregory , Peter Pivonka
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引用次数: 0

摘要

这项研究的重点是人类第四腰椎(L4)在儿科人群中的生长模式,特别关注性别二态性。研究旨在通过与年龄相关的统计形状和统计外观模型来了解椎骨的形态和密度变化,这些模型可以描述完整的三维解剖结构。结果表明,主要的生长模式与各向同性的椎体体积增长、椎孔相对大小的减小以及横突长度的增加有关。此外,青春期还表现出明显的性别二态性。在椎体前部高度方面,我们观察到了明显的年龄和性别交互作用(P = 0.005),其中雌性的椎体高度进化率增长较早。此外,我们还观察到横截面积(CSA)随着年龄的增长而增加(P = 0.020),其中女性的横截面积小于男性(显著性别效应 P = 0.042)。最后,虽然没有观察到骨小梁密度随年龄的增长而明显增加(P = 0.363),但统计外观模型中的趋势表明密度会随着年龄的增长而增加。
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Assessment of age-dependent sexual dimorphism in paediatric vertebral size and density using a statistical shape and statistical appearance modelling approach

This work focuses on the growth patterns of the human fourth lumbar vertebra (L4) in a paediatric population, with specific attention to sexual dimorphism. The study aims to understand morphological and density changes in the vertebrae through age-dependent statistical shape and statistical appearance models, which can describe full three-dimensional anatomy. Results show that the main growth patterns are associated with isotropic volumetric vertebral growth, a decrease in the relative size of the vertebral foramen, and an increase in the length of the transverse processes. Moreover, significant sexual dimorphism was demonstrated during puberty. We observe significant age and sex interaction in the anterior vertebral body height (P = 0.005), where females exhibited an earlier increase in rates of vertebral height evolution. Moreover, we also observe an increase in cross-sectional area (CSA) with age (P = 0.020), where the CSA is smaller in females than in males (significant sex effect P = 0.042). Finally, although no significant increase in trabecular bone density with age is observed (P = 0.363), a trend in the statistical appearance model suggests an increase in density with age.

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来源期刊
Bone
Bone 医学-内分泌学与代谢
CiteScore
8.90
自引率
4.90%
发文量
264
审稿时长
30 days
期刊介绍: BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.
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