Synthetic Strategies of Highly Bioactive Scaffold Bis(indolyl)methane Under Greener Condition- A Comprehensive Review

Bis(indolyl)Methanes are a major class of heterocycles with considerable promise for technological and biological applications and being fluorescent active as well. Considering the extensive quantity of work on various synthetic techniques, the objective of this study is to measure the previous and current status of research studies related to different types of Bis(indolyl)methane (BIM) derivatives. Currently, research is focused on developing green synthetic strategies for dependable, sustainable and environmentally friendly synthetic processes. The present literature describes the formation of BIM moieties starting from suitable precursors using conventional reaction procedures, as well as reactions mediated by microwaves, ultrasounds, organocatalysts, transition metal catalysts, metal-free ionic liquid catalysts, and other environmentally friendly reaction protocols. The current review discusses the explosive development of different environmentally friendly synthesis routes for bis(indolyl)methane and its analogues during the past few decades. Moreover, this study includes the biological activities such as antibacterial, anticancer, anti-inflammatory, etc., of BIM derivatives, which have been investigated in recent years.