Sydney Stanley, Catarina Silva-Costa, Joana Gomes-Silva, Jose Melo-Cristino, Richard Malley, Mario Ramirez
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引用次数: 0
摘要
背景 克隆复合体 180（CC180）是目前血清 3 型肺炎链球菌（Spn）的主要克隆。尽管 13 价肺炎球菌结合疫苗（PCV13）中含有多糖，但对血清 3 型肺炎球菌并无显著疗效。据推测，PCV13 可有效控制 CC180 的支系 I，但支系 III 和支系 IV 却具有抗药性，从而引发群体转变，使血清 3 型得以持续存在。在美国、英格兰和威尔士观察到了这种情况，但在西班牙没有观察到。我们利用葡萄牙的数据集进一步验证了这一假设。
CC180 clade dynamics does not universally explain Streptococcus pneumoniae serotype 3 persistence post-vaccine: a global comparative population genomics study
Background Clonal complex 180 (CC180) is currently the major clone of serotype 3 Streptococcus pneumoniae (Spn). The 13-valent pneumococcal conjugate vaccine (PCV13) does not have significant efficacy against serotype 3 despite polysaccharide inclusion in the vaccine. It was hypothesized that PCV13 may effectively control Clade I of CC180 but that Clades III and IV are resistant, provoking a population shift that enables serotype 3 persistence. This has been observed in the United States, England, and Wales but not Spain. We tested this hypothesis further utilizing a dataset from Portugal.
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