Valeria I. Arkhipova, Elizaveta N. Mochalova, Maxim P. Nikitin
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Au-based bimetallic nanoparticles: current biomedical applications
The rapidly developing field of nanomedicine presents new challenges for researchers. Existing, clinically used preparations based on metal nanoparticles still have their limitations. Consequently, scientific attention is shifting from well-studied monometallic to bimetallic nanoparticles, which combine a synergistic combination of different metals in their composition. This review examines promising gold-containing bimetallic nanoparticles for use in biomedicine. Gold (Au) is the most popular initial choice in bimetallic nanoparticle (BNPs) composition due to its biocompatibility. As two metals combine in one particle, it becomes possible to reduce systemic toxicity and significantly increase the therapeutic effect. We provide a comprehensive assessment of the advantages and limitations of bimetallic nanoparticles and discuss potential solutions to the problems that have hindered their development.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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