免疫细胞外泌体及其对肿瘤的治疗潜力

IF 9.7 4区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS VIEW Pub Date : 2024-09-02 DOI:10.1002/viw.20240029
Hongru Ai, Yitan Zou, Xinya Zheng, Guangyao Li, Changhai Lei, Wenyan Fu, Shi Hu
{"title":"免疫细胞外泌体及其对肿瘤的治疗潜力","authors":"Hongru Ai, Yitan Zou, Xinya Zheng, Guangyao Li, Changhai Lei, Wenyan Fu, Shi Hu","doi":"10.1002/viw.20240029","DOIUrl":null,"url":null,"abstract":"Exosomes are nanoscale membrane vesicles identified by electron microscopy in 1946. They are approximately 30–150 nm in size. Originally, exosomes were thought to be used to eliminate excess components from cells to maintain their normal physiology. Later, it was found that the function and targeting of specific cellular components in exosomes have important implications for the regulation of cellular communication. In the last few years, exosomes have been linked to tumors, infections, and other diseases. New advances in cancer immunotherapy have occurred as a result of the identification of exosomes of immune cell origin, expanding the existing anticancer immune response. This article details exosomes derived from dendritic cells, T lymphocytes (CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and CAR-T cells), natural killer cells, and their promising applications in tumor therapy.","PeriodicalId":34127,"journal":{"name":"VIEW","volume":null,"pages":null},"PeriodicalIF":9.7000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exosomes of immune cell origin and their therapeutic potential for tumors\",\"authors\":\"Hongru Ai, Yitan Zou, Xinya Zheng, Guangyao Li, Changhai Lei, Wenyan Fu, Shi Hu\",\"doi\":\"10.1002/viw.20240029\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Exosomes are nanoscale membrane vesicles identified by electron microscopy in 1946. They are approximately 30–150 nm in size. Originally, exosomes were thought to be used to eliminate excess components from cells to maintain their normal physiology. Later, it was found that the function and targeting of specific cellular components in exosomes have important implications for the regulation of cellular communication. In the last few years, exosomes have been linked to tumors, infections, and other diseases. New advances in cancer immunotherapy have occurred as a result of the identification of exosomes of immune cell origin, expanding the existing anticancer immune response. This article details exosomes derived from dendritic cells, T lymphocytes (CD4<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and CAR-T cells), natural killer cells, and their promising applications in tumor therapy.\",\"PeriodicalId\":34127,\"journal\":{\"name\":\"VIEW\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2024-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"VIEW\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1002/viw.20240029\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"VIEW","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/viw.20240029","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

摘要

外泌体是 1946 年通过电子显微镜确定的纳米级膜囊泡。它们的大小约为 30-150 纳米。最初,外泌体被认为用于清除细胞中多余的成分,以维持细胞的正常生理功能。后来,人们发现外泌体中特定细胞成分的功能和靶向性对细胞通讯的调节有重要影响。最近几年,外泌体与肿瘤、感染和其他疾病有了联系。由于发现了免疫细胞来源的外泌体,癌症免疫疗法取得了新的进展,扩大了现有的抗癌免疫反应。本文详细介绍了源自树突状细胞、T 淋巴细胞(CD4+ T 细胞、CD8+ T 细胞和 CAR-T 细胞)、自然杀伤细胞的外泌体及其在肿瘤治疗中的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Exosomes of immune cell origin and their therapeutic potential for tumors
Exosomes are nanoscale membrane vesicles identified by electron microscopy in 1946. They are approximately 30–150 nm in size. Originally, exosomes were thought to be used to eliminate excess components from cells to maintain their normal physiology. Later, it was found that the function and targeting of specific cellular components in exosomes have important implications for the regulation of cellular communication. In the last few years, exosomes have been linked to tumors, infections, and other diseases. New advances in cancer immunotherapy have occurred as a result of the identification of exosomes of immune cell origin, expanding the existing anticancer immune response. This article details exosomes derived from dendritic cells, T lymphocytes (CD4+ T cells, CD8+ T cells, and CAR-T cells), natural killer cells, and their promising applications in tumor therapy.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
VIEW
VIEW Multiple-
CiteScore
12.60
自引率
2.30%
发文量
0
审稿时长
10 weeks
期刊介绍: View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.
期刊最新文献
Frontiers in artificial intelligence-directed light-sheet microscopy for uncovering biological phenomena and multiorgan imaging Exosomes of immune cell origin and their therapeutic potential for tumors Optical imaging for brown or beige adipose tissue Electrochemical detection of the cardiac biomarker cardiac troponin I Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1