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引用次数: 0
摘要
生化反应是生命系统的基本生物过程，在生物医学、细胞生物学、合成生物学和化学生物学等许多领域也具有重要意义。然而，提高生化反应的效率、速率和可控性仍然是一个永恒的课题。生物系统通过在空间高度有序地排列反应物来精确控制多步生化反应，从而提高级联反应的速率和效率，受此启发，人们采用了许多策略来组织反应物并构建人工生化反应。DNA 自组装技术具有易于编程、可定址、生物相容性好等优点，在改善生化反应方面大有可为。在这篇综述中，我们介绍了生化反应改进策略和 DNA 自组装技术，并总结了近年来 DNA 自组装技术在改进生化反应性能方面的应用进展，包括 DNA 级联反应、酶级联反应、受体反应、细胞器相互作用和细胞-细胞相互作用。我们还介绍了将 DNA 自组装技术应用于生化反应调控和改进的现有挑战和进一步展望。
DNA Self-Assembly: A Tool to Improve Biochemical Reaction Performance
Biochemical reactions are essential biological processes of living systems, which are also significant in many fields, such as biomedicine, cytobiology, synthetic biology, and chemical biology. However, there remains an everlasting requirement for the improvement of efficiency, rate, and controllability of biochemical reactions. Inspired by biological systems that enable precisely controlled multistep biochemical reactions by spatially arranging reactants in a highly organized manner for improving the cascade reaction rate and efficiency, a lot of strategies have been used to organize reactants and construct artificial biochemical reactions. With the advantages of easy programmability, site addressability, and biocompatibility, DNA self-assembly technology has shown great promise in improving biochemical reactions. In this review, we introduce the biochemical reaction improvement strategies and DNA self-assembly technology as well as summarize the recent advances in the applications of DNA self-assembly technology for improving biochemical reaction performances, including DNA cascade reactions, enzyme cascade reactions, receptor reactions, organelle interactions, and cell–cell interactions. We also present the existing challenges and further perspectives of applying DNA self-assembly technology in biochemical reaction regulation and improvement.
期刊介绍：
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.
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