一种能改善肿瘤缺氧并提高放疗疗效的多功能介孔二氧化硅给药纳米系统

IF 8.6 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Npg Asia Materials Pub Date : 2024-08-16 DOI:10.1038/s41427-024-00560-w
Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu
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引用次数: 0

摘要

放疗(RT)是一种广泛使用的治疗方法,具有很强的治疗效果,但克服缺氧引起的肿瘤耐药性和无效的抗肿瘤免疫反应是获得最佳疗效的关键。在这项研究中,我们利用介孔二氧化硅纳米颗粒(MSN)、R837 和少量过氧化锰(Mn/ZnO2)开发了一种多功能纳米系统。合成的 MSN@R837-Mn/ZnO2 纳米粒子具有精确的肿瘤靶向性和蓄积性,在酸性条件下可控制药物释放,并提高了磁共振成像的灵敏度。这些特性通过缓解缺氧和免疫抑制共同提高了 RT 的疗效。肿瘤细胞经与这些纳米颗粒结合的 RT 治疗后,氧化应激减少,缺氧减轻,血管形成正常。值得注意的是,RT + PD-1 + MSN@R837-Mn/ZnO2组的所有小鼠都实现了肿瘤完全消退并延长了生存期。安全性评估证实,MSN@R837-Mn/ZnO2 无毒性,突出了其作为一种具有双重功能的癌症诊断成像和治疗方法的潜力。
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy

Radiotherapy (RT) is a widely used treatment with strong therapeutic effects, but overcoming challenges related to hypoxia-induced tumor resistance and ineffective antitumor immune responses is crucial for optimal outcomes. In this study, we developed a versatile nanosystem using mesoporous silica nanoparticles (MSNs), R837, and a small quantity of manganese peroxide (Mn/ZnO2). The synthesized MSN@R837-Mn/ZnO2 nanoparticles exhibited precise tumor targeting and accumulation, controlled drug release under acidic conditions, and increased sensitivity in magnetic resonance imaging. These attributes collectively augmented the therapeutic efficacy of RT by alleviating hypoxia and immunosuppression. Tumor cells treated with RT combined with these nanoparticles displayed reduced oxidative stress, alleviated hypoxia, and normalized blood vessel formation. Notably, all mice in the RT + PD-1 + MSN@R837-Mn/ZnO2 group achieved complete tumor regression with extended survival. Safety assessments confirmed the absence of MSN@R837-Mn/ZnO2 toxicity, highlighting its potential as a promising approach with dual functionality for the diagnostic imaging and treatment of cancer.

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来源期刊
Npg Asia Materials
Npg Asia Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
15.40
自引率
1.00%
发文量
87
审稿时长
2 months
期刊介绍: NPG Asia Materials is an open access, international journal that publishes peer-reviewed review and primary research articles in the field of materials sciences. The journal has a global outlook and reach, with a base in the Asia-Pacific region to reflect the significant and growing output of materials research from this area. The target audience for NPG Asia Materials is scientists and researchers involved in materials research, covering a wide range of disciplines including physical and chemical sciences, biotechnology, and nanotechnology. The journal particularly welcomes high-quality articles from rapidly advancing areas that bridge the gap between materials science and engineering, as well as the classical disciplines of physics, chemistry, and biology. NPG Asia Materials is abstracted/indexed in Journal Citation Reports/Science Edition Web of Knowledge, Google Scholar, Chemical Abstract Services, Scopus, Ulrichsweb (ProQuest), and Scirus.
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