利用机械化学法实现吡唑酮的无溶剂脱氢 C-H Chalcogenation

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-06 DOI:10.1002/ajoc.202400353

Wenbo Ma, Tao Zheng, Zihan Yu, Junlong Li, Qilin Gu, Linghui Gu, Zheyu Li

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引用次数: 0

摘要

介绍了利用球磨技术使吡唑酮与硫醇发生机械化学交叉脱氢偶联反应。在温和的反应条件下，苯硒醇和二卤化底物也能相容，产率高达 99%。该反应的显著特点包括无金属、无溶剂、底物范围广以及对官能团具有良好的耐受性。初步的机理研究表明，这一 C-H chalcogenation 反应可能涉及自由基途径。

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Solvent‐Free Dehydrogenative C‒H Chalcogenations of Pyrazolones Using Mechanochemistry

A mechanochemical cross‐dehydrogenative coupling reaction of pyrazolones with thiols using ball milling is described. Benzeneselenol and dichalcogenide substrates are also compatible under mild reaction conditions, yielding up to 99%. Notable features of this reaction include its metal‐ and solvent‐free, wide substrate scope and good functional group tolerance. Preliminary mechanistic investigations suggest that a radical pathway is likely involved in this C‒H chalcogenation reaction

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.