钯催化的以甲基烯为酰化试剂的 4-苯基喹啉直接正交 C-H 酰化反应

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC Asian Journal of Organic Chemistry Pub Date : 2024-09-03 DOI:10.1002/ajoc.202400394

Hongjun Zhu, Tongtong Deng, Shan Hu, Xianyu Ying, Hui Wang

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引用次数: 0

摘要

通过 Pd 催化氧化 C-H 活化，开发出了一种简单的 4-苯基喹唑啉正酰化方法，产量适中，其中没有使用预官能化的甲基烯作为酰化试剂。此外，这种方法还可容忍多种官能团。自由基清除实验表明，酰化涉及苯甲酰自由基途径。

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Palladium Catalyzed Direct Ortho C‐H Acylation of 4‐Phenylquinoline using Methylarenes as Acylation Reagents

A simple ortho‐acylation of 4‐phenylquinazoline by a Pd‐catalyzed oxidative C–H activation was developed, with moderate yields, in which no prefunctionalized methylarenes were used as acylation reagents. Moreover, this methodology tolerates a wide range of functional groups. Radical scavenging experiments indicate that the acylation involves a benzoyl radical pathway.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.