利用免疫系统：抗击神经退行性疾病的疫苗

IF 12.8 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in molecular medicine Pub Date : 2024-09-09 DOI:10.1016/j.molmed.2024.08.005

Alba Gonzalez-Artero, Jordi Pujols, Salvador Ventura

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引用次数: 0

摘要

神经退行性疾病严重影响着我们的老龄化社会，而治疗方法只能缓解症状。主动免疫疗法的最新进展通过刺激免疫系统产生针对折叠错误和有毒淀粉样蛋白的抗体，提供了解决方案。我们将讨论正在进行临床评估的阿尔茨海默病和帕金森病疫苗，重点介绍成功案例和正在进行的试验。

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Harnessing the immune system: vaccines to fight neurodegenerative diseases

Neurodegenerative diseases strongly impact our aging society, with treatments providing only symptomatic relief. Recent advancements in active immunotherapy offer solutions by stimulating the immune system to produce antibodies against misfolded and toxic amyloid proteins. We discuss vaccines under clinical evaluation for Alzheimer’s and Parkinson’s diseases, highlighting successes and ongoing trials.

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来源期刊

Trends in molecular medicine 医学-生化与分子生物学

CiteScore

24.60

自引率

0.00%

发文量

142

审稿时长

6-12 weeks

期刊介绍： Trends in Molecular Medicine (TMM) aims to offer concise and contextualized perspectives on the latest research advancing biomedical science toward better diagnosis, treatment, and prevention of human diseases. It focuses on research at the intersection of basic biology and clinical research, covering new concepts in human biology and pathology with clear implications for diagnostics and therapy. TMM reviews bridge the gap between bench and bedside, discussing research from preclinical studies to patient-enrolled trials. The major themes include disease mechanisms, tools and technologies, diagnostics, and therapeutics, with a preference for articles relevant to multiple themes. TMM serves as a platform for discussion, pushing traditional boundaries and fostering collaboration between scientists and clinicians. The journal seeks to publish provocative and authoritative articles that are also accessible to a broad audience, inspiring new directions in molecular medicine to enhance human health.

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