获得功能化 2-噁唑啉的扩环策略（微型综述）

IF 1.4 4区化学 Q3 CHEMISTRY, ORGANIC Chemistry of Heterocyclic Compounds Pub Date : 2024-08-27 DOI:10.1007/s10593-024-03326-y

Leyan Liu, Wentong Liu, Huangdi Feng

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引用次数: 0

摘要

开发用于构建杂环的创新方法是合成化学和药物化学的一个重要课题。在合成各种杂环化合物的过程中，涉及应变氮杂环环化的扩环策略得到了很好的发展。本微综述总结了氮丙啶、氧杂环丁烷和氮杂环丁烷扩环反应的最新进展，以获得一系列功能化 2-噁唑啉，它们是药物和生物活性分子中的多功能结构基团。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ring expansion strategy to access functionalized 2-oxazolines (microreview)

The development of innovative methods for the construction of heterocycles is an important topic in synthetic and medicinal chemistry. Ring expansion strategies, involving the cyclization of strained aza rings, have been well developed in the synthesis of diverse heterocyclic compounds. This microreview summarizes recent advances in the ring expansion reactions of aziridines, oxetanes, and azetidines to access a series of functionalized 2-oxazolines, which are versatile structural motifs in drugs and bioactive molecules.

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来源期刊

Chemistry of Heterocyclic Compounds 化学-有机化学

CiteScore

2.90

自引率

13.30%

发文量

审稿时长

1 months

期刊介绍： The international journal Chemistry of Heterocyclic Compounds publishes original papers, short communications, reviews, and mini-reviews dealing with problems in the field of heterocyclic chemistry in Russian and English. The Journal also publishes reviews and annotations on new books and brief reports on conferences in the field of heterocyclic chemistry, as well as commemoratives dedicated to prominent heterocyclic chemists.