Nora Caroline Wild, Kartik V. Bulusu, Michael W. Plesniak
{"title":"健康和致动脉粥样硬化颈动脉分叉模型中的涡旋动力学","authors":"Nora Caroline Wild, Kartik V. Bulusu, Michael W. Plesniak","doi":"10.1103/physrevfluids.9.083102","DOIUrl":null,"url":null,"abstract":"Carotid artery atherosclerosis is a significant contributor to mortality in the United States. While it is recognized that low wall-shear stresses trigger plaque formation, there is a limited comprehension of the internal vortical structures that impact these stresses and how they differ between a healthy and a disease-prone, high-risk patient cohort. Our objective is to determine which driving factors, such as anatomical features (artery geometry) and mass-flow split, govern vortex behavior. Physiological pulsatile flow computational fluid dynamics simulations were performed on a “healthy” and a “disease-prone” carotid artery bifurcation model. Geometry and flow effects are investigated separately by simulating a third hybrid model having a healthy geometry with outlet boundary conditions imposing disease-prone flow conditions. This “unhealthy <math xmlns=\"http://www.w3.org/1998/Math/MathML\"><mrow><mi mathvariant=\"normal\">Δ</mi><mi mathvariant=\"normal\">P</mi></mrow></math>” model recreated disease-prone mass-flow split and internal carotid artery sinus axial pressure gradient conditions in a healthy carotid artery bifurcation geometry. The results of our study revealed that the main vortex's time of formation is primarily dictated by carotid artery bifurcation geometry, whereas its lifespan is determined by the flow conditions. The main vortex's spatial expansion, as well as its circulation decay rate, are dictated by the geometry, not the flow conditions. We conclude that a high internal carotid artery mass flow rate and a higher favorable pressure gradient maximum magnitude occurring near peak systole are strong indicators of a high predisposition towards atherogenesis.","PeriodicalId":20160,"journal":{"name":"Physical Review Fluids","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Vortex dynamics in healthy and pro-atherogenic carotid artery bifurcation models\",\"authors\":\"Nora Caroline Wild, Kartik V. Bulusu, Michael W. Plesniak\",\"doi\":\"10.1103/physrevfluids.9.083102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Carotid artery atherosclerosis is a significant contributor to mortality in the United States. While it is recognized that low wall-shear stresses trigger plaque formation, there is a limited comprehension of the internal vortical structures that impact these stresses and how they differ between a healthy and a disease-prone, high-risk patient cohort. Our objective is to determine which driving factors, such as anatomical features (artery geometry) and mass-flow split, govern vortex behavior. Physiological pulsatile flow computational fluid dynamics simulations were performed on a “healthy” and a “disease-prone” carotid artery bifurcation model. Geometry and flow effects are investigated separately by simulating a third hybrid model having a healthy geometry with outlet boundary conditions imposing disease-prone flow conditions. This “unhealthy <math xmlns=\\\"http://www.w3.org/1998/Math/MathML\\\"><mrow><mi mathvariant=\\\"normal\\\">Δ</mi><mi mathvariant=\\\"normal\\\">P</mi></mrow></math>” model recreated disease-prone mass-flow split and internal carotid artery sinus axial pressure gradient conditions in a healthy carotid artery bifurcation geometry. The results of our study revealed that the main vortex's time of formation is primarily dictated by carotid artery bifurcation geometry, whereas its lifespan is determined by the flow conditions. The main vortex's spatial expansion, as well as its circulation decay rate, are dictated by the geometry, not the flow conditions. We conclude that a high internal carotid artery mass flow rate and a higher favorable pressure gradient maximum magnitude occurring near peak systole are strong indicators of a high predisposition towards atherogenesis.\",\"PeriodicalId\":20160,\"journal\":{\"name\":\"Physical Review Fluids\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physical Review Fluids\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1103/physrevfluids.9.083102\",\"RegionNum\":3,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSICS, FLUIDS & PLASMAS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physical Review Fluids","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1103/physrevfluids.9.083102","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSICS, FLUIDS & PLASMAS","Score":null,"Total":0}
Vortex dynamics in healthy and pro-atherogenic carotid artery bifurcation models
Carotid artery atherosclerosis is a significant contributor to mortality in the United States. While it is recognized that low wall-shear stresses trigger plaque formation, there is a limited comprehension of the internal vortical structures that impact these stresses and how they differ between a healthy and a disease-prone, high-risk patient cohort. Our objective is to determine which driving factors, such as anatomical features (artery geometry) and mass-flow split, govern vortex behavior. Physiological pulsatile flow computational fluid dynamics simulations were performed on a “healthy” and a “disease-prone” carotid artery bifurcation model. Geometry and flow effects are investigated separately by simulating a third hybrid model having a healthy geometry with outlet boundary conditions imposing disease-prone flow conditions. This “unhealthy ” model recreated disease-prone mass-flow split and internal carotid artery sinus axial pressure gradient conditions in a healthy carotid artery bifurcation geometry. The results of our study revealed that the main vortex's time of formation is primarily dictated by carotid artery bifurcation geometry, whereas its lifespan is determined by the flow conditions. The main vortex's spatial expansion, as well as its circulation decay rate, are dictated by the geometry, not the flow conditions. We conclude that a high internal carotid artery mass flow rate and a higher favorable pressure gradient maximum magnitude occurring near peak systole are strong indicators of a high predisposition towards atherogenesis.
期刊介绍:
Physical Review Fluids is APS’s newest online-only journal dedicated to publishing innovative research that will significantly advance the fundamental understanding of fluid dynamics. Physical Review Fluids expands the scope of the APS journals to include additional areas of fluid dynamics research, complements the existing Physical Review collection, and maintains the same quality and reputation that authors and subscribers expect from APS. The journal is published with the endorsement of the APS Division of Fluid Dynamics.