{"title":"与术后疼痛有关的肥大细胞 BH4-羟色胺代谢网络","authors":"Alexandra Flemming","doi":"10.1038/s41577-024-01089-3","DOIUrl":null,"url":null,"abstract":"Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstrate that this can be therapeutically targeted in mouse models.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":null,"pages":null},"PeriodicalIF":67.7000,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mast cell BH4–serotonin metabolic network implicated in postoperative pain\",\"authors\":\"Alexandra Flemming\",\"doi\":\"10.1038/s41577-024-01089-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstrate that this can be therapeutically targeted in mouse models.\",\"PeriodicalId\":19049,\"journal\":{\"name\":\"Nature Reviews Immunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":67.7000,\"publicationDate\":\"2024-09-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41577-024-01089-3\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41577-024-01089-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Mast cell BH4–serotonin metabolic network implicated in postoperative pain
Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstrate that this can be therapeutically targeted in mouse models.
期刊介绍：
Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
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