{"title":"泰国暹罗乌蔹莓枝条中的一种新的兰氏三萜类化合物","authors":"Ngoc-Hong Nguyen, Boi-Phong Vuong, Dinh-Manh Nguyen, Thuc-Huy Duong, Hoang-Thanh Kpa, Thi-Kim-Dung Le, Thi-Ngoc-Duyen Nguyen, Huy Truong Nguyen, Jirapast Sichaem","doi":"10.1007/s10600-024-04467-4","DOIUrl":null,"url":null,"abstract":"<p>A new lanostane-type triterpene, uvariaol (<b>1</b>), was isolated from the branches of Thai <i>Uvaria siamensis</i>, along with three known compounds, polycarpol (<b>2</b>), fisetinidol (<b>3</b>), and stigmast-4-en-3-one (<b>4</b>). Their structures were elucidated through extensive spectroscopic analyses and comparison with existing literature. The <i>α</i>-glucosidase inhibitory potential of compounds <b>1–4</b> was evaluated. Compound <b>1</b> exhibited significant inhibitory activity against <i>α</i>-glucosidase, surpassing the potency of the positive control, with an IC<sub>50</sub> value of 30.8 ± 1.5 μM.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A New Lanostane-Type Triterpene from the Branches of Thai Uvaria siamensis\",\"authors\":\"Ngoc-Hong Nguyen, Boi-Phong Vuong, Dinh-Manh Nguyen, Thuc-Huy Duong, Hoang-Thanh Kpa, Thi-Kim-Dung Le, Thi-Ngoc-Duyen Nguyen, Huy Truong Nguyen, Jirapast Sichaem\",\"doi\":\"10.1007/s10600-024-04467-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A new lanostane-type triterpene, uvariaol (<b>1</b>), was isolated from the branches of Thai <i>Uvaria siamensis</i>, along with three known compounds, polycarpol (<b>2</b>), fisetinidol (<b>3</b>), and stigmast-4-en-3-one (<b>4</b>). Their structures were elucidated through extensive spectroscopic analyses and comparison with existing literature. The <i>α</i>-glucosidase inhibitory potential of compounds <b>1–4</b> was evaluated. Compound <b>1</b> exhibited significant inhibitory activity against <i>α</i>-glucosidase, surpassing the potency of the positive control, with an IC<sub>50</sub> value of 30.8 ± 1.5 μM.</p>\",\"PeriodicalId\":514,\"journal\":{\"name\":\"Chemistry of Natural Compounds\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry of Natural Compounds\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10600-024-04467-4\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-024-04467-4","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
A New Lanostane-Type Triterpene from the Branches of Thai Uvaria siamensis
A new lanostane-type triterpene, uvariaol (1), was isolated from the branches of Thai Uvaria siamensis, along with three known compounds, polycarpol (2), fisetinidol (3), and stigmast-4-en-3-one (4). Their structures were elucidated through extensive spectroscopic analyses and comparison with existing literature. The α-glucosidase inhibitory potential of compounds 1–4 was evaluated. Compound 1 exhibited significant inhibitory activity against α-glucosidase, surpassing the potency of the positive control, with an IC50 value of 30.8 ± 1.5 μM.
期刊介绍：
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.
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