用于炎症生物标记物监测的灵活电化学类肤平台

IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Macromolecular bioscience Pub Date : 2024-09-18 DOI:10.1002/mabi.202400287
Carolina Lourenço, Felismina Moreira, Rui Igreja, Gabriela Martins
{"title":"用于炎症生物标记物监测的灵活电化学类肤平台","authors":"Carolina Lourenço, Felismina Moreira, Rui Igreja, Gabriela Martins","doi":"10.1002/mabi.202400287","DOIUrl":null,"url":null,"abstract":"Addressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift has accelerated the development of new skin patch sensors for continuous health monitoring. A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) is customized for the detection of the inflammatory biomarker interleukin‐6 (IL‐6). The 3‐electrode gold pattern is geometrically standardized onto a 6 µm thick polyimide flexible membrane, an optically transparent, and biocompatible polymeric substrate. Subsequently, a biomimetic sensing layer specifically designed for the detection of IL‐6 target is produced on these transducers. The obtained MIP biosensor shows a good linear response within the concentration range 50 pg mL<jats:sup>−1</jats:sup>‐50 ng mL<jats:sup>−1</jats:sup>, with a low limit of detection (8 pg mL<jats:sup>−1</jats:sup>). X‐ray photoelectron spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy characterizations confirm the modifications of the flexible gold transducer. After optimization, the biosensing device shows remarkable potential in terms of sensitivity, selectivity, and reproducibility. Overall, the integration of a low‐cost electrochemical sensor on biocompatible flexible polymers opens the way for a new generation of monitoring tools with higher accuracy, less invasiveness, and greater patient comfort.","PeriodicalId":18103,"journal":{"name":"Macromolecular bioscience","volume":null,"pages":null},"PeriodicalIF":4.4000,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flexible, Electrochemical Skin‐Like Platform for Inflammatory Biomarker Monitoring\",\"authors\":\"Carolina Lourenço, Felismina Moreira, Rui Igreja, Gabriela Martins\",\"doi\":\"10.1002/mabi.202400287\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Addressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift has accelerated the development of new skin patch sensors for continuous health monitoring. A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) is customized for the detection of the inflammatory biomarker interleukin‐6 (IL‐6). The 3‐electrode gold pattern is geometrically standardized onto a 6 µm thick polyimide flexible membrane, an optically transparent, and biocompatible polymeric substrate. Subsequently, a biomimetic sensing layer specifically designed for the detection of IL‐6 target is produced on these transducers. The obtained MIP biosensor shows a good linear response within the concentration range 50 pg mL<jats:sup>−1</jats:sup>‐50 ng mL<jats:sup>−1</jats:sup>, with a low limit of detection (8 pg mL<jats:sup>−1</jats:sup>). X‐ray photoelectron spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy characterizations confirm the modifications of the flexible gold transducer. After optimization, the biosensing device shows remarkable potential in terms of sensitivity, selectivity, and reproducibility. Overall, the integration of a low‐cost electrochemical sensor on biocompatible flexible polymers opens the way for a new generation of monitoring tools with higher accuracy, less invasiveness, and greater patient comfort.\",\"PeriodicalId\":18103,\"journal\":{\"name\":\"Macromolecular bioscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2024-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Macromolecular bioscience\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1002/mabi.202400287\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Macromolecular bioscience","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/mabi.202400287","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

应对全球伤口管理方面的挑战极大地促进了家庭诊断和监测设备的出现。这一技术转变加速了用于持续健康监测的新型皮肤贴片传感器的开发。一个关键的要求是创建能够模仿人体皮肤特征的灵活平台。在这里,我们首次利用分子印迹聚合物(MIPs)定制了一种创新的、适应性强的电化学生物传感器,用于检测炎症生物标志物白细胞介素-6(IL-6)。在 6 微米厚的聚酰亚胺柔性膜(一种光学透明、生物兼容的聚合物基底)上,对 3 个电极的金图案进行了几何标准化。随后,在这些传感器上制作了专为检测 IL-6 目标而设计的仿生物传感层。获得的 MIP 生物传感器在 50 pg mL-1-50 ng mL-1 的浓度范围内显示出良好的线性响应,检测限低(8 pg mL-1)。X 射线光电子能谱、扫描电子显微镜和傅立叶变换红外光谱表征证实了柔性金传感器的改性。经过优化后,该生物传感装置在灵敏度、选择性和再现性方面都显示出显著的潜力。总之,在生物相容性柔性聚合物上集成低成本电化学传感器,为开发新一代监测工具开辟了道路,这种监测工具具有更高的准确性、更低的侵入性和更高的病人舒适度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Flexible, Electrochemical Skin‐Like Platform for Inflammatory Biomarker Monitoring
Addressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift has accelerated the development of new skin patch sensors for continuous health monitoring. A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) is customized for the detection of the inflammatory biomarker interleukin‐6 (IL‐6). The 3‐electrode gold pattern is geometrically standardized onto a 6 µm thick polyimide flexible membrane, an optically transparent, and biocompatible polymeric substrate. Subsequently, a biomimetic sensing layer specifically designed for the detection of IL‐6 target is produced on these transducers. The obtained MIP biosensor shows a good linear response within the concentration range 50 pg mL−1‐50 ng mL−1, with a low limit of detection (8 pg mL−1). X‐ray photoelectron spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy characterizations confirm the modifications of the flexible gold transducer. After optimization, the biosensing device shows remarkable potential in terms of sensitivity, selectivity, and reproducibility. Overall, the integration of a low‐cost electrochemical sensor on biocompatible flexible polymers opens the way for a new generation of monitoring tools with higher accuracy, less invasiveness, and greater patient comfort.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Macromolecular bioscience
Macromolecular bioscience 生物-材料科学:生物材料
CiteScore
7.90
自引率
2.20%
发文量
211
审稿时长
1.5 months
期刊介绍: Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
期刊最新文献
Surface Coating of ZIF-8 Nanoparticles with Polyacrylic Acid: A Facile Approach to Enhance Chemical Stability for Biomedical Applications. Biocompatible Zn-Phthalocyanine/Gelatin Nanofiber Membrane for Antibacterial Therapy. The Application of Biomaterial-Based Spinal Cord Tissue Engineering. Applications of Diels-Alder Chemistry in Biomaterials and Drug Delivery. Manufacturing Radially Aligned PCL Nanofibers Reinforced With Sulfated Levan and Evaluation of its Biological Activity for Healing Tympanic Membrane Perforations.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1