药物引起的高尿酸血症

IF 4 2区医学 Q1 PHARMACOLOGY & PHARMACY Drug Safety Pub Date : 2024-09-17 DOI:10.1007/s40264-024-01485-7

Chaker Ben Salem, Myriam Agrebi, Dhouha Sahnoun, Neila Fathallah, Houssem Hmouda

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摘要

高尿酸血症是指血清尿酸浓度≤ 2.0 mg/dL 或 119 μmol/L。高尿酸血症可能继发于多种基础疾病，包括严重的肝细胞疾病、肿瘤、肾小管对尿酸的重吸收缺陷、遗传性嘌呤代谢缺陷和药物。药物是导致高尿酸血症的一个重要原因。药物可通过多种机制引起低尿酸血症。药物引起的高尿酸血症大多是由于降尿酸治疗（包括黄嘌呤氧化酶抑制剂、尿酸盐制剂和尿酸酶）过度治疗高尿酸血症所致。未用于治疗痛风的药物也可能导致尿酸水平下降。本文献综述总结了导致低尿酸血症的药物的作用机制和临床意义。

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Drug-Induced Hypouricemia

Hypouricemia is defined as a serum uric acid concentration of ≤ 2.0 mg/dL or 119 μmol/L. Hypouricemia may occur secondarily to a number of underlying conditions, including severe hepatocellular disease, neoplasia, defective renal tubular reabsorption of uric acid, inherited metabolic defect in purine metabolism, and drugs. Medications are an important cause of hypouricemia. They can cause hypouricemia by a variety of mechanisms. Drug-induced hypouricemia mostly occurs as overtreatment of hyperuricemia by urate-lowering therapies including xanthine oxidase inhibitors, uricosuric agents and uricases. Drugs not used in the treatment of gout may also lead to a decrease of uric acid levels. In this literature review, medications leading to hypouricemia are summarized with regard to their mechanism of action and clinical significance.

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来源期刊

Drug Safety 医学-毒理学

CiteScore

7.60

自引率

7.10%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Drug Safety is the official journal of the International Society of Pharmacovigilance. The journal includes: Overviews of contentious or emerging issues. Comprehensive narrative reviews that provide an authoritative source of information on epidemiology, clinical features, prevention and management of adverse effects of individual drugs and drug classes. In-depth benefit-risk assessment of adverse effect and efficacy data for a drug in a defined therapeutic area. Systematic reviews (with or without meta-analyses) that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. Original research articles reporting the results of well-designed studies in disciplines such as pharmacoepidemiology, pharmacovigilance, pharmacology and toxicology, and pharmacogenomics. Editorials and commentaries on topical issues. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Drug Safety Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.