东南亚人群中人类表皮生长因子受体 2 低表达转移性乳腺癌的发病率和预后价值:一项为期 10 年的回顾性研究。

IF 3.2 Q2 ONCOLOGY JCO Global Oncology Pub Date : 2024-09-01 DOI:10.1200/GO.24.00132
Thanate Dajsakdipon, Wiriya Pipatsakulroj, Thitiya Dejthevaporn
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引用次数: 0

摘要

目的:不同分子亚型的乳腺癌进展各不相同,与HER2过表达肿瘤相比,人表皮生长因子受体2(HER2)低表达肿瘤的治疗方案有限。目前还缺乏有关东南亚人群中转移性HER2低表达乳腺癌流行病学和临床结果的全面信息:这项回顾性队列研究分析了新发晚期乳腺癌患者的数据,包括 HER2 表达、肿瘤分期和转移模式。统计分析包括卡方检验和生存分析,用于比较HER2低表达组和HER2阴性组:结果:在491名患者中,21.2%为HER2低表达组,30%为HER2过表达组,50%为HER2阴性表达组。在激素受体(HR)阳性患者中,34%有HER2低表达;在三阴性患者中,HER2低表达发生率为20.6%。除了HER2-低表达组中HR阳性患者较多之外,HER2-低表达组和HER2-阴性组的临床特征没有明显差异。与HER2阴性患者相比,HER2低患者的总生存期(OS)更长(43个月对23个月;危险比,0.7;P < .001),尤其是在HR阳性患者中。调整HR状态后,HER2低患者的预后仍有所改善。与HR阳性HER2阴性患者相比,HR阳性HER2低患者的OS改善不显著,与一线化疗或内分泌治疗无关:这项研究揭示了HER2低表达在新发晚期乳腺癌中的发生率和临床结果,提示了良好的预后,尤其是在HR阳性乳腺癌中。这些发现可为个性化治疗策略提供依据。关于乳腺癌中HER2低表达的机制和影响还需要进一步研究。
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Incidence and Prognostic Values in Human Epidermal Growth Factor Receptor 2-Low Expression Metastatic Breast Cancer in Southeast Asian Population: A 10-Year Retrospective Study.

Purpose: Breast cancer progression varies across molecular subtypes, and treatment options for human epidermal growth factor receptor 2 (HER2)-low expression tumors are limited compared with those of HER2 overexpression tumors. Comprehensive information regarding the epidemiology and clinical outcomes of metastatic HER2-low expression breast cancer in a Southeast Asian population is lacking.

Methods: This retrospective cohort study was performed to analyze data from patients with de novo advanced breast cancer, including HER2 expression, tumor stage, and metastatic pattern. Statistical analyses, including chi-square tests and survival analyses, were used to compare HER2-low expression and HER2-negative groups.

Results: Of the 491 patients, 21.2% had HER2-low expression, 30% had HER2 overexpression, and 50% had HER2-negative expression. Among the hormone receptor (HR)-positive patients, 34% had HER2-low expression; in the triple-negative patients, the HER2-low incidence was 20.6%. No significant differences in clinical characteristics between HER2-low and HER2-negative groups were observed, except for more HR-positive patients in the HER2-low group. HER2-low patients had a longer overall survival (OS) than HER2-negative patients (43 v 23 months; hazard ratio, 0.7; P < .001), especially in HR-positive patients. After adjusting for HR status, HER2-low patients maintained improved outcomes. HR-positive HER2-low patients showed nonsignificant OS gains compared with HR-positive HER2-negative patients, regardless of first-line chemotherapy or endocrine therapy.

Conclusion: This study revealed the incidence and clinical outcomes of HER2-low expression in de novo advanced breast cancer, suggesting favorable outcomes, particularly in HR-positive breast cancer. These findings may inform personalized treatment strategies. Further research into the mechanisms and implications of HER2-low expression in breast cancer is required.

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来源期刊
JCO Global Oncology
JCO Global Oncology Medicine-Oncology
CiteScore
6.70
自引率
6.70%
发文量
310
审稿时长
7 weeks
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