氯霉素在蛋白质-能量营养不良的年轻恒河猴中的处理。

Drug-nutrient interactions Pub Date : 1986-01-01

B Sharma, S Mehta, C K Nain, V S Mathur

{"title":"氯霉素在蛋白质-能量营养不良的年轻恒河猴中的处理。","authors":"B Sharma, S Mehta, C K Nain, V S Mathur","doi":"","DOIUrl":null,"url":null,"abstract":"The disposition of chloramphenicol was studied in young rhesus monkeys at three levels of nutrition: control, protein-energy deficiency, and following nutritional rehabilitation. During the malnutrition phase, the plasma elimination half-life was prolonged and the plasma clearance was reduced. Simultaneously there was a decrease in the activity of chloramphenicol-specific UDP-glucuronyl transferase. These changes were reversible following nutritional rehabilitation.","PeriodicalId":11372,"journal":{"name":"Drug-nutrient interactions","volume":"4 4","pages":"333-8"},"PeriodicalIF":0.0000,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Disposition of chloramphenicol in young rhesus monkeys with protein-energy malnutrition.\",\"authors\":\"B Sharma, S Mehta, C K Nain, V S Mathur\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The disposition of chloramphenicol was studied in young rhesus monkeys at three levels of nutrition: control, protein-energy deficiency, and following nutritional rehabilitation. During the malnutrition phase, the plasma elimination half-life was prolonged and the plasma clearance was reduced. Simultaneously there was a decrease in the activity of chloramphenicol-specific UDP-glucuronyl transferase. These changes were reversible following nutritional rehabilitation.\",\"PeriodicalId\":11372,\"journal\":{\"name\":\"Drug-nutrient interactions\",\"volume\":\"4 4\",\"pages\":\"333-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1986-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug-nutrient interactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug-nutrient interactions","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

在三个营养水平下研究了年轻恒河猴对氯霉素的处置:控制、蛋白质能量缺乏和营养康复。在营养不良期，血浆消除半衰期延长，血浆清除率降低。同时，氯霉素特异性udp -葡萄糖醛酸转移酶活性降低。这些变化在营养康复后是可逆的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Disposition of chloramphenicol in young rhesus monkeys with protein-energy malnutrition.

The disposition of chloramphenicol was studied in young rhesus monkeys at three levels of nutrition: control, protein-energy deficiency, and following nutritional rehabilitation. During the malnutrition phase, the plasma elimination half-life was prolonged and the plasma clearance was reduced. Simultaneously there was a decrease in the activity of chloramphenicol-specific UDP-glucuronyl transferase. These changes were reversible following nutritional rehabilitation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Drug-nutrient interactions

自引率

0.00%

发文量