呼吸门控 4D PET/CT 扫描运动校正对确定膈肌附近病变特征的影响 - 一家三级医疗机构的横断面研究。

IF 0.4 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Indian Journal of Nuclear Medicine Pub Date : 2024-05-01 Epub Date: 2024-08-17 DOI:10.4103/ijnm.ijnm_142_23
Sai Sradha P Patro, Parag Aland, Vivek Mathew James, Vikram Lele
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引用次数: 0

摘要

目的:呼吸运动造成的模糊会增加膈肌附近病变的表观大小并降低其代谢活性,从而降低全身 F-18 氟脱氧葡萄糖正电子发射计算机断层扫描(18F-FDG PET-CT)诊断的准确性。本研究旨在评估基于四维相位的呼吸门控(RG)18F-FDG PET-CT 运动校正在改善膈邻近病变(尤其是肺或肝)代谢参数方面的效果:18例已知肺部或肝部病变的患者接受了传统的18F-FDG PET-CT检查,并使用基于压力感应和相位的呼吸门控系统对所需区域进行了呼吸门控PET-CT采集。从门控和非门控 PET-CT 图像中获得这些病变的最大标准化摄取值(SUVmax)、代谢肿瘤体积(MTV)和总病变糖酵解率(TLG),以便进行分析。此外,还对病灶进行了肉眼分析:RG图像参数的统计学意义通过双尾配对学生t检验进行评估,并通过稳健的非参数Wilcoxon符号秩检验(双尾渐近)进行确认:在所有选取方法中,SUVmax总体上都有明显增加(P 0.001),百分比增幅最大约为18.13%。与非门控方法相比,门控方法的 MTV 显著下降(P = 0.001)(最大下降约 32.9%)。结论:结论:基于相位的呼吸门控运动校正提高了 18F-FDG PET-CT 成像对肺部和肝脏病变的诊断价值,能更准确地划分病变体积和量化 SUV,从而对选定患者的分期、诊断和治疗产生影响。
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Impact of Respiratory-gated 4D PET/CT Scan for Motion Correction in Characterizing Lesions Adjacent to the Diaphragm - A Cross-sectional Study at a Tertiary Care Institute.

Purpose: The blur introduced by breathing motion degrades the diagnostic accuracy of whole-body F-18 fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) in lesions adjacent to the diaphragm by increasing the apparent size and by decreasing their metabolic activity. This study aims to evaluate the efficacy of motion correction by four-dimensional phase-based respiratory-gated (RG) 18F-FDG PET-CT in improving metabolic parameters of lesions adjacent to the diaphragm (especially in the lungs or liver).

Materials and methods: Eighteen patients with known lung or liver lesions underwent conventional 18F-FDG PET-CT and respiratory-gated PET-CT acquisition of the desired region using a pressure-sensing, phase-based respiratory-gating system. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained for these lesions from gated and nongated PET-CT images for analysis. Furthermore, a visual analysis of lesions was done.

Statistics: Statistical significance of the RG image parameters was assessed by the two-tailed paired Student's t test and confirmed with the robust nonparametric Wilcoxon's signed-rank test (two-tailed asymptotic).

Results: There was an overall significant increase in SUVmax (P 0.001) in all gating methods with a percentage increase maximum of about 18.13%. On gating methods, MTV decreased significantly (P = 0.001) than that of nongating method (maximum reduction of about 32.9%). There was a significant difference (P = 0.02) in TLG between gated and nongated methods.

Conclusion: Motion correction with phase-based respiratory gating improves the diagnostic value of 18F-FDG PET-CT imaging for lung and liver lesions by more accurate delineation of the lesion volume and quantitation of SUV and can thus impact staging, diagnosis as well as management in selected patients.

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来源期刊
Indian Journal of Nuclear Medicine
Indian Journal of Nuclear Medicine RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.70
自引率
0.00%
发文量
46
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