用于光声成像的超小型生物相容性近红外-II 造影剂波恩石（Cu5FeS4）纳米晶体

IF 7.1 1区医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2024-09-17 DOI:10.1016/j.pacs.2024.100649

Vinoin Devpaul Vincely , Xingjian Zhong , Kristie Huda , Swathi P. Katakam , Joshua C. Kays , Allison M. Dennis , Carolyn L. Bayer

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引用次数: 0

摘要

在这项研究中，我们证明了硫化铜铁的波长石晶体结构（Cu5FeS4）作为第二种近红外（NIR-II）光声（PA）对比剂的潜力。在用 HepG2 细胞进行的细胞存活率研究中，波长石表现出与硫化铜纳米粒子相当的剂量依赖性生物相容性，同时 PA 振幅增加了 10 倍。与质量浓度相近的其他基准造影剂相比，波来石的 PA 振幅比吲哚菁绿（ICG）增加了 10 倍，比金纳米棒（AuNRs）增加了 5 倍。在保持体外细胞活力的情况下，波来石浓度在猪组织模型中的光路长度大于 5 厘米时就能检测到 PA 信号。与 AuNRs 相比，小鼠血管的体内成像使 PA 振幅增加了 2 倍。总之，波来石是一种很有前途的用于深部组织 PA 成像的 NIR-II 造影剂。

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Bornite (Cu5FeS4) nanocrystals as an ultrasmall biocompatible NIR-II contrast agent for photoacoustic imaging

In this study, we demonstrate the potential of the bornite crystal structure (Cu₅FeS₄) of copper iron sulfide as a second near infrared (NIR-II) photoacoustic (PA) contrast agent. Bornite exhibits comparable dose-dependent biocompatibility to copper sulfide nanoparticles in a cell viability study with HepG2 cells, while exhibiting a 10-fold increase in PA amplitude. In comparison to other benchmark contrast agents at similar mass concentrations, bornite demonstrated a 10× increase in PA amplitude compared to indocyanine green (ICG) and a 5× increase compared to gold nanorods (AuNRs). PA signal was detectable with a light pathlength greater than 5 cm in porcine tissue phantoms at bornite concentrations where in vitro cell viability was maintained. In vivo imaging of mice vasculature resulted in a 2× increase in PA amplitude compared to AuNRs. In summary, bornite is a promising NIR-II contrast agent for deep tissue PA imaging.

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来源期刊

Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics

CiteScore

11.40

自引率

16.50%

发文量

审稿时长

53 days

期刊介绍： The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.